Fine scale mapping of a genetic locus for conditioned fear.
Fear conditioning is one of a number of models for investigating the genetic basis of individual variation in emotion and learning. Genetic mapping using crosses between strains of laboratory mice has identified a locus on chromosome one that appears to influence not only variation in conditioned fe...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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| _version_ | 1797061853899128832 |
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| author | Talbot, C Radcliffe, R Fullerton, J Hitzemann, R Wehner, J Flint, J |
| author_facet | Talbot, C Radcliffe, R Fullerton, J Hitzemann, R Wehner, J Flint, J |
| author_sort | Talbot, C |
| collection | OXFORD |
| description | Fear conditioning is one of a number of models for investigating the genetic basis of individual variation in emotion and learning. Genetic mapping using crosses between strains of laboratory mice has identified a locus on chromosome one that appears to influence not only variation in conditioned fear, but also in other validated tests of fear-related behaviour, (including the open-field and the elevated-plus maze), suggesting that the rodent locus may act in ways consistent with how a locus influencing susceptibility to anxiety in humans is believed to operate. Here we use high-resolution mapping in genetically heterogeneous mice to show that a quantitative trait locus influencing conditioned fear can be separated from loci influencing open-field activity. Mapping in two different heterogeneous stocks, the Boulder and Northport HS, gave similar map locations for open-field activity at two positions on the current mouse physical map, one at 162 Mb on chromosome one (negative log P-value 5.4) the other at 173 Mb (negative log P-value 4.8), while mapping of contextual conditioned fear in the Boulder HS identified a locus at 170 Mb (negative log P-value 5.4). Estimates of the 95% confidence intervals show that the locations do not overlap. The region containing a gene or genes that influence variation in conditioned fear is approximately 1 megabase in size and contains only one gene of known function, a pre-B cell leukaemia factor. |
| first_indexed | 2024-03-06T20:37:06Z |
| format | Journal article |
| id | oxford-uuid:330356fc-4243-45f2-9f7c-bca40726edc8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:37:06Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:330356fc-4243-45f2-9f7c-bca40726edc82022-03-26T13:17:36ZFine scale mapping of a genetic locus for conditioned fear.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:330356fc-4243-45f2-9f7c-bca40726edc8EnglishSymplectic Elements at Oxford2003Talbot, CRadcliffe, RFullerton, JHitzemann, RWehner, JFlint, JFear conditioning is one of a number of models for investigating the genetic basis of individual variation in emotion and learning. Genetic mapping using crosses between strains of laboratory mice has identified a locus on chromosome one that appears to influence not only variation in conditioned fear, but also in other validated tests of fear-related behaviour, (including the open-field and the elevated-plus maze), suggesting that the rodent locus may act in ways consistent with how a locus influencing susceptibility to anxiety in humans is believed to operate. Here we use high-resolution mapping in genetically heterogeneous mice to show that a quantitative trait locus influencing conditioned fear can be separated from loci influencing open-field activity. Mapping in two different heterogeneous stocks, the Boulder and Northport HS, gave similar map locations for open-field activity at two positions on the current mouse physical map, one at 162 Mb on chromosome one (negative log P-value 5.4) the other at 173 Mb (negative log P-value 4.8), while mapping of contextual conditioned fear in the Boulder HS identified a locus at 170 Mb (negative log P-value 5.4). Estimates of the 95% confidence intervals show that the locations do not overlap. The region containing a gene or genes that influence variation in conditioned fear is approximately 1 megabase in size and contains only one gene of known function, a pre-B cell leukaemia factor. |
| spellingShingle | Talbot, C Radcliffe, R Fullerton, J Hitzemann, R Wehner, J Flint, J Fine scale mapping of a genetic locus for conditioned fear. |
| title | Fine scale mapping of a genetic locus for conditioned fear. |
| title_full | Fine scale mapping of a genetic locus for conditioned fear. |
| title_fullStr | Fine scale mapping of a genetic locus for conditioned fear. |
| title_full_unstemmed | Fine scale mapping of a genetic locus for conditioned fear. |
| title_short | Fine scale mapping of a genetic locus for conditioned fear. |
| title_sort | fine scale mapping of a genetic locus for conditioned fear |
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