Advanced robotics to address the translational gap in tendon engineering
Tendon disease is a significant and growing burden to healthcare systems. One strategy to address this challenge is tissue engineering. A widely held view in this field is that mechanical stimulation provided to constructs should replicate the mechanical environment of native tissue as closely as po...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Association for the Advancement of Science
2022
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| _version_ | 1797108284367306752 |
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| author | Sander, IL Dvorak, N Stebbins, JA Carr, AJ Mouthuy, P-A |
| author_facet | Sander, IL Dvorak, N Stebbins, JA Carr, AJ Mouthuy, P-A |
| author_sort | Sander, IL |
| collection | OXFORD |
| description | Tendon disease is a significant and growing burden to healthcare systems. One strategy to address this challenge is tissue engineering. A widely held view in this field is that mechanical stimulation provided to constructs should replicate the mechanical environment of native tissue as closely as possible. We review recent tendon tissue engineering studies in this article and highlight limitations of conventional uniaxial tensile bioreactors used in current literature. Advanced robotic platforms such as musculoskeletal humanoid robots and soft robotic actuators are promising technologies which may help address translational gaps in tendon tissue engineering. We suggest the proposed benefits of these technologies and identify recent studies which have worked to implement these technologies in tissue engineering. Lastly, key challenges to address in adapting these robotic technologies and proposed future research directions for tendon tissue engineering are discussed. |
| first_indexed | 2024-03-07T07:27:02Z |
| format | Journal article |
| id | oxford-uuid:330378cd-1ab6-4e7a-af19-a1ba15e3abe9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:27:02Z |
| publishDate | 2022 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:330378cd-1ab6-4e7a-af19-a1ba15e3abe92022-12-01T17:21:39ZAdvanced robotics to address the translational gap in tendon engineeringJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:330378cd-1ab6-4e7a-af19-a1ba15e3abe9EnglishSymplectic ElementsAmerican Association for the Advancement of Science2022Sander, ILDvorak, NStebbins, JACarr, AJMouthuy, P-ATendon disease is a significant and growing burden to healthcare systems. One strategy to address this challenge is tissue engineering. A widely held view in this field is that mechanical stimulation provided to constructs should replicate the mechanical environment of native tissue as closely as possible. We review recent tendon tissue engineering studies in this article and highlight limitations of conventional uniaxial tensile bioreactors used in current literature. Advanced robotic platforms such as musculoskeletal humanoid robots and soft robotic actuators are promising technologies which may help address translational gaps in tendon tissue engineering. We suggest the proposed benefits of these technologies and identify recent studies which have worked to implement these technologies in tissue engineering. Lastly, key challenges to address in adapting these robotic technologies and proposed future research directions for tendon tissue engineering are discussed. |
| spellingShingle | Sander, IL Dvorak, N Stebbins, JA Carr, AJ Mouthuy, P-A Advanced robotics to address the translational gap in tendon engineering |
| title | Advanced robotics to address the translational gap in tendon engineering |
| title_full | Advanced robotics to address the translational gap in tendon engineering |
| title_fullStr | Advanced robotics to address the translational gap in tendon engineering |
| title_full_unstemmed | Advanced robotics to address the translational gap in tendon engineering |
| title_short | Advanced robotics to address the translational gap in tendon engineering |
| title_sort | advanced robotics to address the translational gap in tendon engineering |
| work_keys_str_mv | AT sanderil advancedroboticstoaddressthetranslationalgapintendonengineering AT dvorakn advancedroboticstoaddressthetranslationalgapintendonengineering AT stebbinsja advancedroboticstoaddressthetranslationalgapintendonengineering AT carraj advancedroboticstoaddressthetranslationalgapintendonengineering AT mouthuypa advancedroboticstoaddressthetranslationalgapintendonengineering |