Stem cell therapy for the heart: blind alley or magic bullet?
When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to n...
| Main Authors: | , , , |
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| Format: | Journal article |
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Springer
2016
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| _version_ | 1826266331729625088 |
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| author | Bruyneel, A Sehgal, A Malandraki-Miller, S Carr, C |
| author_facet | Bruyneel, A Sehgal, A Malandraki-Miller, S Carr, C |
| author_sort | Bruyneel, A |
| collection | OXFORD |
| description | When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to new cardiomyocytes and vasculature. Unfortunately, the results from clinical trials to date have been largely disappointing. In this review, we discuss the current status of the field and describe various limitations and how future work may attempt to resolve these to make way to successful clinical translation. |
| first_indexed | 2024-03-06T20:37:17Z |
| format | Journal article |
| id | oxford-uuid:330e197e-4c27-4e56-a990-b41529b7133d |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:37:17Z |
| publishDate | 2016 |
| publisher | Springer |
| record_format | dspace |
| spelling | oxford-uuid:330e197e-4c27-4e56-a990-b41529b7133d2022-03-26T13:17:57ZStem cell therapy for the heart: blind alley or magic bullet?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:330e197e-4c27-4e56-a990-b41529b7133dSymplectic Elements at OxfordSpringer2016Bruyneel, ASehgal, AMalandraki-Miller, SCarr, CWhen stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to new cardiomyocytes and vasculature. Unfortunately, the results from clinical trials to date have been largely disappointing. In this review, we discuss the current status of the field and describe various limitations and how future work may attempt to resolve these to make way to successful clinical translation. |
| spellingShingle | Bruyneel, A Sehgal, A Malandraki-Miller, S Carr, C Stem cell therapy for the heart: blind alley or magic bullet? |
| title | Stem cell therapy for the heart: blind alley or magic bullet? |
| title_full | Stem cell therapy for the heart: blind alley or magic bullet? |
| title_fullStr | Stem cell therapy for the heart: blind alley or magic bullet? |
| title_full_unstemmed | Stem cell therapy for the heart: blind alley or magic bullet? |
| title_short | Stem cell therapy for the heart: blind alley or magic bullet? |
| title_sort | stem cell therapy for the heart blind alley or magic bullet |
| work_keys_str_mv | AT bruyneela stemcelltherapyfortheheartblindalleyormagicbullet AT sehgala stemcelltherapyfortheheartblindalleyormagicbullet AT malandrakimillers stemcelltherapyfortheheartblindalleyormagicbullet AT carrc stemcelltherapyfortheheartblindalleyormagicbullet |