Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2.
Prostaglandin D2 (PGD2) acting at the CRTH2 receptor (chemoattractant receptor-homologous molecule expressed on Th2 cells) has been linked with a variety of allergic and other inflammatory diseases. We describe a family of indole-1-sulfonyl-3-acetic acids that are potent and selective CRTH2 antagoni...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1797061896150450176 |
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| author | Armer, R Ashton, MR Boyd, E Brennan, C Brookfield, F Gazi, L Gyles, S Hay, P Hunter, MG Middlemiss, D Whittaker, M Xue, L Pettipher, R |
| author_facet | Armer, R Ashton, MR Boyd, E Brennan, C Brookfield, F Gazi, L Gyles, S Hay, P Hunter, MG Middlemiss, D Whittaker, M Xue, L Pettipher, R |
| author_sort | Armer, R |
| collection | OXFORD |
| description | Prostaglandin D2 (PGD2) acting at the CRTH2 receptor (chemoattractant receptor-homologous molecule expressed on Th2 cells) has been linked with a variety of allergic and other inflammatory diseases. We describe a family of indole-1-sulfonyl-3-acetic acids that are potent and selective CRTH2 antagonists that possess good oral bioavailability. The compounds may serve as novel starting points for the development of treatments of inflammatory disease such as asthma, allergic rhinitis, and atopic dermatitis. |
| first_indexed | 2024-03-06T20:37:43Z |
| format | Journal article |
| id | oxford-uuid:332f36c4-a5f1-4646-a493-e0090518e706 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:37:43Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:332f36c4-a5f1-4646-a493-e0090518e7062022-03-26T13:18:50ZIndole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:332f36c4-a5f1-4646-a493-e0090518e706EnglishSymplectic Elements at Oxford2005Armer, RAshton, MRBoyd, EBrennan, CBrookfield, FGazi, LGyles, SHay, PHunter, MGMiddlemiss, DWhittaker, MXue, LPettipher, RProstaglandin D2 (PGD2) acting at the CRTH2 receptor (chemoattractant receptor-homologous molecule expressed on Th2 cells) has been linked with a variety of allergic and other inflammatory diseases. We describe a family of indole-1-sulfonyl-3-acetic acids that are potent and selective CRTH2 antagonists that possess good oral bioavailability. The compounds may serve as novel starting points for the development of treatments of inflammatory disease such as asthma, allergic rhinitis, and atopic dermatitis. |
| spellingShingle | Armer, R Ashton, MR Boyd, E Brennan, C Brookfield, F Gazi, L Gyles, S Hay, P Hunter, MG Middlemiss, D Whittaker, M Xue, L Pettipher, R Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. |
| title | Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. |
| title_full | Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. |
| title_fullStr | Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. |
| title_full_unstemmed | Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. |
| title_short | Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. |
| title_sort | indole 3 acetic acid antagonists of the prostaglandin d2 receptor crth2 |
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