Changes in number of NK cells after one year from coronary artery bypass graft

Natural Killer cells (NK cells) are components of nonspecific immune response involved in the defense against viral and bacterial infections. Basing on the CD56 cell surface antigen density human NK cells may be divided into two distinct subpopulations: CD56dim - "cytotoxic subset" and CD5...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs: Hak, L, Wieckiewicz, J, Mysliwska, J, Szyndler, K, Siebert, J, Rogowski, J
Formaat: Journal article
Taal:English
Gepubliceerd in: Termedia Publishing House Ltd. 2009
_version_ 1826266383169617920
author Hak, L
Wieckiewicz, J
Mysliwska, J
Szyndler, K
Siebert, J
Rogowski, J
author_facet Hak, L
Wieckiewicz, J
Mysliwska, J
Szyndler, K
Siebert, J
Rogowski, J
author_sort Hak, L
collection OXFORD
description Natural Killer cells (NK cells) are components of nonspecific immune response involved in the defense against viral and bacterial infections. Basing on the CD56 cell surface antigen density human NK cells may be divided into two distinct subpopulations: CD56dim - "cytotoxic subset" and CD56bright - "regulatory subset". Our previous work revealed that coronary heart disease (CHD) patients are characterized by a reduction in absolute values and percentage of the CD3-CD56dim and CD3-CD56+ cells. CHD is inflammation dependent disease. Therefore we decided to estimate NK cells status in CHD patients after one year from coronary artery bypass graft (CABG). This procedure improves the heart and vascular status in patients and also remove inflammatory burden. Blood was collected from eighty five patients from the Clinic of Cardiosurgery of the Medical University of Gdańsk before CABG. Blood from eleven CHD patients was examined ones more after one year from CABG. Seventy seven people, of similar age, with excluded coronary heart disease were enrolled into the study as a control group. Percentage of the CD3-CD56+, CD3-CD56dim and CD3-CD56bright cells were analyzed in all samples by flow cytometry. Before CABG blood of the CHD patients was characterized by a low percentage of the CD3-CD56+ and CD3-CD56dim subsets in comparison to control group. However when number of cells were analyzed within one year after CABG we observed a rise of the CD3-CD56+ and CD3-CD56dim cells percentage. The increase of cell percentage was relevant when data were compared to control group and to the results obtained from CHD group before CABG. It may be concluded that a lower NK cells number in CHD is a consequence of inflammation and further that this number may be treated as marker of inflammation.
first_indexed 2024-03-06T20:38:05Z
format Journal article
id oxford-uuid:334db04b-d594-46a6-8cdb-1c963451ca6c
institution University of Oxford
language English
last_indexed 2024-03-06T20:38:05Z
publishDate 2009
publisher Termedia Publishing House Ltd.
record_format dspace
spelling oxford-uuid:334db04b-d594-46a6-8cdb-1c963451ca6c2022-03-26T13:19:32ZChanges in number of NK cells after one year from coronary artery bypass graftJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:334db04b-d594-46a6-8cdb-1c963451ca6cEnglishSymplectic Elements at OxfordTermedia Publishing House Ltd.2009Hak, LWieckiewicz, JMysliwska, JSzyndler, KSiebert, JRogowski, JNatural Killer cells (NK cells) are components of nonspecific immune response involved in the defense against viral and bacterial infections. Basing on the CD56 cell surface antigen density human NK cells may be divided into two distinct subpopulations: CD56dim - "cytotoxic subset" and CD56bright - "regulatory subset". Our previous work revealed that coronary heart disease (CHD) patients are characterized by a reduction in absolute values and percentage of the CD3-CD56dim and CD3-CD56+ cells. CHD is inflammation dependent disease. Therefore we decided to estimate NK cells status in CHD patients after one year from coronary artery bypass graft (CABG). This procedure improves the heart and vascular status in patients and also remove inflammatory burden. Blood was collected from eighty five patients from the Clinic of Cardiosurgery of the Medical University of Gdańsk before CABG. Blood from eleven CHD patients was examined ones more after one year from CABG. Seventy seven people, of similar age, with excluded coronary heart disease were enrolled into the study as a control group. Percentage of the CD3-CD56+, CD3-CD56dim and CD3-CD56bright cells were analyzed in all samples by flow cytometry. Before CABG blood of the CHD patients was characterized by a low percentage of the CD3-CD56+ and CD3-CD56dim subsets in comparison to control group. However when number of cells were analyzed within one year after CABG we observed a rise of the CD3-CD56+ and CD3-CD56dim cells percentage. The increase of cell percentage was relevant when data were compared to control group and to the results obtained from CHD group before CABG. It may be concluded that a lower NK cells number in CHD is a consequence of inflammation and further that this number may be treated as marker of inflammation.
spellingShingle Hak, L
Wieckiewicz, J
Mysliwska, J
Szyndler, K
Siebert, J
Rogowski, J
Changes in number of NK cells after one year from coronary artery bypass graft
title Changes in number of NK cells after one year from coronary artery bypass graft
title_full Changes in number of NK cells after one year from coronary artery bypass graft
title_fullStr Changes in number of NK cells after one year from coronary artery bypass graft
title_full_unstemmed Changes in number of NK cells after one year from coronary artery bypass graft
title_short Changes in number of NK cells after one year from coronary artery bypass graft
title_sort changes in number of nk cells after one year from coronary artery bypass graft
work_keys_str_mv AT hakl changesinnumberofnkcellsafteroneyearfromcoronaryarterybypassgraft
AT wieckiewiczj changesinnumberofnkcellsafteroneyearfromcoronaryarterybypassgraft
AT mysliwskaj changesinnumberofnkcellsafteroneyearfromcoronaryarterybypassgraft
AT szyndlerk changesinnumberofnkcellsafteroneyearfromcoronaryarterybypassgraft
AT siebertj changesinnumberofnkcellsafteroneyearfromcoronaryarterybypassgraft
AT rogowskij changesinnumberofnkcellsafteroneyearfromcoronaryarterybypassgraft