Loss of gas from echogenic liposomes exposed to pulsed ultrasound.
The destruction of echogenic liposomes (ELIP) in response to pulsed ultrasound excitations has been studied acoustically previously. However, the mechanism underlying the loss of echogenicity due to cavitation nucleated by ELIP has not been fully clarified. In this study, an ultra-high speed imaging...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Institute of Physics
2016
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| _version_ | 1797061953753972736 |
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| author | Raymond, J Luan, Y Peng, T Huang, S McPherson, D Versluis, M de Jong, N Holland, C |
| author_facet | Raymond, J Luan, Y Peng, T Huang, S McPherson, D Versluis, M de Jong, N Holland, C |
| author_sort | Raymond, J |
| collection | OXFORD |
| description | The destruction of echogenic liposomes (ELIP) in response to pulsed ultrasound excitations has been studied acoustically previously. However, the mechanism underlying the loss of echogenicity due to cavitation nucleated by ELIP has not been fully clarified. In this study, an ultra-high speed imaging approach was employed to observe the destruction phenomena of single ELIP exposed to ultrasound bursts at a center frequency of 6 MHz. We observed a rapid size reduction during the ultrasound excitation in 139 out of 397 (35%) ultra- high-speed recordings. The shell dilation rate, which is defined as the microbubble wall velocity divided by the instantaneous radius, [Formula: see text] /R, was extracted from the radius versus time response of each ELIP, and was found to be correlated with the deflation. Fragmentation and surface mode vibrations were also observed and are shown to depend on the applied acoustic pressure and initial radius. Results from this study can be utilized to optimize the theranostic application of ELIP, e.g. by tuning the size distribution or the excitation frequency. |
| first_indexed | 2024-03-06T20:38:35Z |
| format | Journal article |
| id | oxford-uuid:3377a1f0-5f17-4501-abc1-196811d4262b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:38:35Z |
| publishDate | 2016 |
| publisher | Institute of Physics |
| record_format | dspace |
| spelling | oxford-uuid:3377a1f0-5f17-4501-abc1-196811d4262b2022-03-26T13:20:31ZLoss of gas from echogenic liposomes exposed to pulsed ultrasound.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3377a1f0-5f17-4501-abc1-196811d4262bEnglishSymplectic Elements at OxfordInstitute of Physics2016Raymond, JLuan, YPeng, THuang, SMcPherson, DVersluis, Mde Jong, NHolland, CThe destruction of echogenic liposomes (ELIP) in response to pulsed ultrasound excitations has been studied acoustically previously. However, the mechanism underlying the loss of echogenicity due to cavitation nucleated by ELIP has not been fully clarified. In this study, an ultra-high speed imaging approach was employed to observe the destruction phenomena of single ELIP exposed to ultrasound bursts at a center frequency of 6 MHz. We observed a rapid size reduction during the ultrasound excitation in 139 out of 397 (35%) ultra- high-speed recordings. The shell dilation rate, which is defined as the microbubble wall velocity divided by the instantaneous radius, [Formula: see text] /R, was extracted from the radius versus time response of each ELIP, and was found to be correlated with the deflation. Fragmentation and surface mode vibrations were also observed and are shown to depend on the applied acoustic pressure and initial radius. Results from this study can be utilized to optimize the theranostic application of ELIP, e.g. by tuning the size distribution or the excitation frequency. |
| spellingShingle | Raymond, J Luan, Y Peng, T Huang, S McPherson, D Versluis, M de Jong, N Holland, C Loss of gas from echogenic liposomes exposed to pulsed ultrasound. |
| title | Loss of gas from echogenic liposomes exposed to pulsed ultrasound. |
| title_full | Loss of gas from echogenic liposomes exposed to pulsed ultrasound. |
| title_fullStr | Loss of gas from echogenic liposomes exposed to pulsed ultrasound. |
| title_full_unstemmed | Loss of gas from echogenic liposomes exposed to pulsed ultrasound. |
| title_short | Loss of gas from echogenic liposomes exposed to pulsed ultrasound. |
| title_sort | loss of gas from echogenic liposomes exposed to pulsed ultrasound |
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