LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.

Aggrecan is a major matrix component of articular cartilage, and its degradation is a crucial event in the development of osteoarthritis (OA). Adamalysin-like metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is a major aggrecan-degrading enzyme in cartilage, but there is no clear correlatio...

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Bibliographic Details
Main Authors:	Yamamoto, K, Troeberg, L, Scilabra, S, Pelosi, M, Murphy, C, Strickland, D, Nagase, H
Format:	Journal article
Language:	English
Published:	2013

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