Different growth patterns of non-small cell lung cancer represent distinct biologic subtypes.
BACKGROUND: We have recently shown the prognostic value of growth pattern classification in non-small cell lung cancer. The aim of this study is to validate the hypothesis that these growth patterns have a distinct angiogenic and proliferative profile. METHODS: Hematoxylin-eosin stained tissue sect...
| Hauptverfasser: | , , , , , , |
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| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
2008
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| _version_ | 1826266444257558528 |
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| author | Sardari Nia, P Colpaert, C Vermeulen, P Weyler, J Pezzella, F Van Schil, P Van Marck, E |
| author_facet | Sardari Nia, P Colpaert, C Vermeulen, P Weyler, J Pezzella, F Van Schil, P Van Marck, E |
| author_sort | Sardari Nia, P |
| collection | OXFORD |
| description | BACKGROUND: We have recently shown the prognostic value of growth pattern classification in non-small cell lung cancer. The aim of this study is to validate the hypothesis that these growth patterns have a distinct angiogenic and proliferative profile. METHODS: Hematoxylin-eosin stained tissue sections of 239 patients with non-small cell lung cancer were classified into growth patterns. One representative tissue section per patient was double immunostained with CD34 and Ki-67 antibodies. Endothelial cell proliferation fraction, tumor cell proliferation fraction, microvessel density, and Chalkley count were assessed at the invading front and the center of the selected tumor section. RESULTS: According to the growth pattern classification, 161 patients (67.4%) had a destructive, 33 (13.8%) a papillary, and 45 (18.8%) an alveolar growth pattern. There were significant differences in endothelial cell proliferation fraction (p < 0.001), tumor cell proliferation fraction (p < 0.001), microvessel density (p < 0.001), and Chalkley count (p < 0.001) between the growth patterns. Multiple Cox regression analysis showed that a low endothelial cell proliferation fraction was consistently an independent prognostic factor for overall poor (hazard ratio = 0.93; confidence interval: 0.88 to 0.97, p = 0.002) and disease-free survival (hazard ratio = 0.94; confidence interval: 0.89 to 0.98, p = 0.007). CONCLUSIONS: Growth patterns have a distinct angiogenic and proliferative profile. In non-small cell lung cancer, a low degree of angiogenesis (a low endothelial cell proliferation fraction) is associated with poor prognosis. |
| first_indexed | 2024-03-06T20:39:03Z |
| format | Journal article |
| id | oxford-uuid:33a66ed5-6a79-4165-add8-6d39de9efb86 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:39:03Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:33a66ed5-6a79-4165-add8-6d39de9efb862022-03-26T13:21:19ZDifferent growth patterns of non-small cell lung cancer represent distinct biologic subtypes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:33a66ed5-6a79-4165-add8-6d39de9efb86EnglishSymplectic Elements at Oxford2008Sardari Nia, PColpaert, CVermeulen, PWeyler, JPezzella, FVan Schil, PVan Marck, E BACKGROUND: We have recently shown the prognostic value of growth pattern classification in non-small cell lung cancer. The aim of this study is to validate the hypothesis that these growth patterns have a distinct angiogenic and proliferative profile. METHODS: Hematoxylin-eosin stained tissue sections of 239 patients with non-small cell lung cancer were classified into growth patterns. One representative tissue section per patient was double immunostained with CD34 and Ki-67 antibodies. Endothelial cell proliferation fraction, tumor cell proliferation fraction, microvessel density, and Chalkley count were assessed at the invading front and the center of the selected tumor section. RESULTS: According to the growth pattern classification, 161 patients (67.4%) had a destructive, 33 (13.8%) a papillary, and 45 (18.8%) an alveolar growth pattern. There were significant differences in endothelial cell proliferation fraction (p < 0.001), tumor cell proliferation fraction (p < 0.001), microvessel density (p < 0.001), and Chalkley count (p < 0.001) between the growth patterns. Multiple Cox regression analysis showed that a low endothelial cell proliferation fraction was consistently an independent prognostic factor for overall poor (hazard ratio = 0.93; confidence interval: 0.88 to 0.97, p = 0.002) and disease-free survival (hazard ratio = 0.94; confidence interval: 0.89 to 0.98, p = 0.007). CONCLUSIONS: Growth patterns have a distinct angiogenic and proliferative profile. In non-small cell lung cancer, a low degree of angiogenesis (a low endothelial cell proliferation fraction) is associated with poor prognosis. |
| spellingShingle | Sardari Nia, P Colpaert, C Vermeulen, P Weyler, J Pezzella, F Van Schil, P Van Marck, E Different growth patterns of non-small cell lung cancer represent distinct biologic subtypes. |
| title | Different growth patterns of non-small cell lung cancer represent distinct biologic subtypes. |
| title_full | Different growth patterns of non-small cell lung cancer represent distinct biologic subtypes. |
| title_fullStr | Different growth patterns of non-small cell lung cancer represent distinct biologic subtypes. |
| title_full_unstemmed | Different growth patterns of non-small cell lung cancer represent distinct biologic subtypes. |
| title_short | Different growth patterns of non-small cell lung cancer represent distinct biologic subtypes. |
| title_sort | different growth patterns of non small cell lung cancer represent distinct biologic subtypes |
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