Whole tumour kinetics analysis of 18F-fluoromisonidazole dynamic PET scans of non-small cell lung cancer patients, and correlations with perfusion CT blood flow
<p>Background: To determine the relative abilities of compartment models to describe time-courses of 18F-fluoromisonidazole (FMISO) tumour uptake in patients with advanced stage non-small cell lung cancer (NSCLC) imaged using dynamic positron emission tomography (dPET), and study correlations...
| প্রধান লেখক: | , , , , , , , |
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| বিন্যাস: | Journal article |
| প্রকাশিত: |
Springer Open
2018
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| _version_ | 1826266457395167232 |
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| author | McGowan, D Skwarski, M Papiez, B Macpherson, R Gleeson, F Schnabel, J Higgins, G Fenwick, J |
| author_facet | McGowan, D Skwarski, M Papiez, B Macpherson, R Gleeson, F Schnabel, J Higgins, G Fenwick, J |
| author_sort | McGowan, D |
| collection | OXFORD |
| description | <p>Background: To determine the relative abilities of compartment models to describe time-courses of 18F-fluoromisonidazole (FMISO) tumour uptake in patients with advanced stage non-small cell lung cancer (NSCLC) imaged using dynamic positron emission tomography (dPET), and study correlations between values of the blood flow-related parameter K1 obtained from fits of the models and an independent blood flow measure obtained from perfusion CT (pCT). </p><p> Methods: NSCLC patients had a 45 minute dynamic FMISO PET/CT scan followed by two static PET/CT acquisitions at two and four hours post-injection. Perfusion CT scanning was then performed consisting of a 45 second cine CT. Reversible and irreversible two-, three- and four-tissue compartment models were fitted to 30 time-activity-curves (TACs) obtained for 15 whole tumour structures in 9 patients, each imaged twice. Descriptions of the TACs provided by the models were compared using the Akaike and Bayesian information criteria (AIC and BIC) and leave-one-out cross-validation. The precision with which fitted model parameters estimated ground-truth uptake kinetics was determined using statistical simulation techniques. Blood flow from pCT was correlated with K1 from PET kinetic models in addition to FMISO uptake levels.</p><p> Results: An irreversible three-tissue compartment model provided the best description of whole tumour FMISO uptake time-courses according to AIC, BIC and cross-validation scores totaled across the TACs. The simulation study indicated that this model also provided more precise estimates of FMISO uptake kinetics than other two- and three-tissue models. The K1 values obtained from fits of the irreversible three-tissue model correlated strongly with independent blood flow measurements obtained from pCT (Pearson r coefficient = 0.81). The correlation from the irreversible three-tissue model (r=0.81) was stronger than that from than K1 values obtained from fits of a two-tissue compartment model (r=0.68), or FMISO uptake levels in static images taken at time-points from tracer injection through to four hours later (maximum at two minutes, r=0.70).</p><p> Conclusions: Time-courses of whole tumour FMISO uptake by advanced stage NSCLC are described best by an irreversible three-tissue compartment model. The K1 values obtained from fits of the irreversible three-tissue model correlated strongly with independent blood flow measurements obtained from perfusion CT (r=0.81).</p> |
| first_indexed | 2024-03-06T20:39:14Z |
| format | Journal article |
| id | oxford-uuid:33b569cf-c3fc-4772-b146-387dc241f4a6 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:39:14Z |
| publishDate | 2018 |
| publisher | Springer Open |
| record_format | dspace |
| spelling | oxford-uuid:33b569cf-c3fc-4772-b146-387dc241f4a62022-03-26T13:21:52ZWhole tumour kinetics analysis of 18F-fluoromisonidazole dynamic PET scans of non-small cell lung cancer patients, and correlations with perfusion CT blood flowJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:33b569cf-c3fc-4772-b146-387dc241f4a6Symplectic Elements at OxfordSpringer Open2018McGowan, DSkwarski, MPapiez, BMacpherson, RGleeson, FSchnabel, JHiggins, GFenwick, J<p>Background: To determine the relative abilities of compartment models to describe time-courses of 18F-fluoromisonidazole (FMISO) tumour uptake in patients with advanced stage non-small cell lung cancer (NSCLC) imaged using dynamic positron emission tomography (dPET), and study correlations between values of the blood flow-related parameter K1 obtained from fits of the models and an independent blood flow measure obtained from perfusion CT (pCT). </p><p> Methods: NSCLC patients had a 45 minute dynamic FMISO PET/CT scan followed by two static PET/CT acquisitions at two and four hours post-injection. Perfusion CT scanning was then performed consisting of a 45 second cine CT. Reversible and irreversible two-, three- and four-tissue compartment models were fitted to 30 time-activity-curves (TACs) obtained for 15 whole tumour structures in 9 patients, each imaged twice. Descriptions of the TACs provided by the models were compared using the Akaike and Bayesian information criteria (AIC and BIC) and leave-one-out cross-validation. The precision with which fitted model parameters estimated ground-truth uptake kinetics was determined using statistical simulation techniques. Blood flow from pCT was correlated with K1 from PET kinetic models in addition to FMISO uptake levels.</p><p> Results: An irreversible three-tissue compartment model provided the best description of whole tumour FMISO uptake time-courses according to AIC, BIC and cross-validation scores totaled across the TACs. The simulation study indicated that this model also provided more precise estimates of FMISO uptake kinetics than other two- and three-tissue models. The K1 values obtained from fits of the irreversible three-tissue model correlated strongly with independent blood flow measurements obtained from pCT (Pearson r coefficient = 0.81). The correlation from the irreversible three-tissue model (r=0.81) was stronger than that from than K1 values obtained from fits of a two-tissue compartment model (r=0.68), or FMISO uptake levels in static images taken at time-points from tracer injection through to four hours later (maximum at two minutes, r=0.70).</p><p> Conclusions: Time-courses of whole tumour FMISO uptake by advanced stage NSCLC are described best by an irreversible three-tissue compartment model. The K1 values obtained from fits of the irreversible three-tissue model correlated strongly with independent blood flow measurements obtained from perfusion CT (r=0.81).</p> |
| spellingShingle | McGowan, D Skwarski, M Papiez, B Macpherson, R Gleeson, F Schnabel, J Higgins, G Fenwick, J Whole tumour kinetics analysis of 18F-fluoromisonidazole dynamic PET scans of non-small cell lung cancer patients, and correlations with perfusion CT blood flow |
| title | Whole tumour kinetics analysis of 18F-fluoromisonidazole dynamic PET scans of non-small cell lung cancer patients, and correlations with perfusion CT blood flow |
| title_full | Whole tumour kinetics analysis of 18F-fluoromisonidazole dynamic PET scans of non-small cell lung cancer patients, and correlations with perfusion CT blood flow |
| title_fullStr | Whole tumour kinetics analysis of 18F-fluoromisonidazole dynamic PET scans of non-small cell lung cancer patients, and correlations with perfusion CT blood flow |
| title_full_unstemmed | Whole tumour kinetics analysis of 18F-fluoromisonidazole dynamic PET scans of non-small cell lung cancer patients, and correlations with perfusion CT blood flow |
| title_short | Whole tumour kinetics analysis of 18F-fluoromisonidazole dynamic PET scans of non-small cell lung cancer patients, and correlations with perfusion CT blood flow |
| title_sort | whole tumour kinetics analysis of 18f fluoromisonidazole dynamic pet scans of non small cell lung cancer patients and correlations with perfusion ct blood flow |
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