Progress towards safer and more effective radical cure of Plasmodium vivax
Plasmodium vivax causes a substantial burden of disease in the Americas, the Horn of Africa, and Asia-Pacific. The parasite forms dormant liver stages (hypnozoites) that reactivate weeks to months after an initial infection causing recurrent episodes of malaria (relapses). Multiple recurrences are a...
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| Format: | Journal article |
| Language: | English |
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Elsevier
2024
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| _version_ | 1826314372015718400 |
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| author | Price, RN |
| author_facet | Price, RN |
| author_sort | Price, RN |
| collection | OXFORD |
| description | Plasmodium vivax causes a substantial burden of disease in the Americas, the Horn of Africa, and Asia-Pacific. The parasite forms dormant liver stages (hypnozoites) that reactivate weeks to months after an initial infection causing recurrent episodes of malaria (relapses). Multiple recurrences are associated with a cumulative risk of anaemia, significant morbidity, and mortality. An estimated 60–90% of vivax malaria cases are attributable to relapses, and these drive the ongoing transmission of the parasite. The elimination of both blood and liver stage parasite (known as radical cure) is crucial for the timely elimination of P vivax. |
| first_indexed | 2024-04-09T03:55:52Z |
| format | Journal article |
| id | oxford-uuid:33bcc1b6-518f-42c6-811d-9092bdc05de4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:33:07Z |
| publishDate | 2024 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:33bcc1b6-518f-42c6-811d-9092bdc05de42024-09-05T09:09:52ZProgress towards safer and more effective radical cure of Plasmodium vivaxJournal articlehttp://purl.org/coar/resource_type/c_6501uuid:33bcc1b6-518f-42c6-811d-9092bdc05de4EnglishSymplectic ElementsElsevier2024Price, RNPlasmodium vivax causes a substantial burden of disease in the Americas, the Horn of Africa, and Asia-Pacific. The parasite forms dormant liver stages (hypnozoites) that reactivate weeks to months after an initial infection causing recurrent episodes of malaria (relapses). Multiple recurrences are associated with a cumulative risk of anaemia, significant morbidity, and mortality. An estimated 60–90% of vivax malaria cases are attributable to relapses, and these drive the ongoing transmission of the parasite. The elimination of both blood and liver stage parasite (known as radical cure) is crucial for the timely elimination of P vivax. |
| spellingShingle | Price, RN Progress towards safer and more effective radical cure of Plasmodium vivax |
| title | Progress towards safer and more effective radical cure of Plasmodium vivax |
| title_full | Progress towards safer and more effective radical cure of Plasmodium vivax |
| title_fullStr | Progress towards safer and more effective radical cure of Plasmodium vivax |
| title_full_unstemmed | Progress towards safer and more effective radical cure of Plasmodium vivax |
| title_short | Progress towards safer and more effective radical cure of Plasmodium vivax |
| title_sort | progress towards safer and more effective radical cure of plasmodium vivax |
| work_keys_str_mv | AT pricern progresstowardssaferandmoreeffectiveradicalcureofplasmodiumvivax |