Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP.

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP.

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Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause late-onset Parkinson's disease, but its physiological function has remained largely unknown. Here we report that LRRK2 activates a calcium-dependent protein kinase kinase-β (CaMKK-β)/adenosine monophosphate (AMP)-activated protein...

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Bibliographic Details
Main Authors: Gómez-Suaga, P, Luzón-Toro, B, Churamani, D, Zhang, L, Bloor-Young, D, Patel, S, Woodman, P, Churchill, G, Hilfiker, S
Format: Journal article
Language:English
Published: 2012

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