Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP.
Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause late-onset Parkinson's disease, but its physiological function has remained largely unknown. Here we report that LRRK2 activates a calcium-dependent protein kinase kinase-β (CaMKK-β)/adenosine monophosphate (AMP)-activated protein...
Հիմնական հեղինակներ: | , , , , , , , , |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
2012
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Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
Հրապարակվել է 2012
Journal article