Admixture into and within sub-Saharan Africa
Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the stru...
| المؤلفون الرئيسيون: | , , , , , , , , , , , , , , , |
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| التنسيق: | Journal article |
| منشور في: |
eLife Science Publications Limited
2016
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| _version_ | 1826266506571284480 |
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| author | Busby, G Band, G Le, Q Jallow, M Bougama, E Mangana, V Amengo-Etego, L Enimil, A Apinjoh, T Ndila, C Manjurano, A Nyirongo, V Doumbo, O Rockett, K Kwiatkowski, D Spencer, C |
| author_facet | Busby, G Band, G Le, Q Jallow, M Bougama, E Mangana, V Amengo-Etego, L Enimil, A Apinjoh, T Ndila, C Manjurano, A Nyirongo, V Doumbo, O Rockett, K Kwiatkowski, D Spencer, C |
| author_sort | Busby, G |
| collection | OXFORD |
| description | Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7,000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4,000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology. |
| first_indexed | 2024-03-06T20:39:59Z |
| format | Journal article |
| id | oxford-uuid:33f58c0d-85d7-477f-89f2-0413ba356e0d |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:39:59Z |
| publishDate | 2016 |
| publisher | eLife Science Publications Limited |
| record_format | dspace |
| spelling | oxford-uuid:33f58c0d-85d7-477f-89f2-0413ba356e0d2022-03-26T13:23:10ZAdmixture into and within sub-Saharan AfricaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:33f58c0d-85d7-477f-89f2-0413ba356e0dSymplectic Elements at OxfordeLife Science Publications Limited2016Busby, GBand, GLe, QJallow, MBougama, EMangana, VAmengo-Etego, LEnimil, AApinjoh, TNdila, CManjurano, ANyirongo, VDoumbo, ORockett, KKwiatkowski, DSpencer, CSimilarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7,000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4,000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology. |
| spellingShingle | Busby, G Band, G Le, Q Jallow, M Bougama, E Mangana, V Amengo-Etego, L Enimil, A Apinjoh, T Ndila, C Manjurano, A Nyirongo, V Doumbo, O Rockett, K Kwiatkowski, D Spencer, C Admixture into and within sub-Saharan Africa |
| title | Admixture into and within sub-Saharan Africa |
| title_full | Admixture into and within sub-Saharan Africa |
| title_fullStr | Admixture into and within sub-Saharan Africa |
| title_full_unstemmed | Admixture into and within sub-Saharan Africa |
| title_short | Admixture into and within sub-Saharan Africa |
| title_sort | admixture into and within sub saharan africa |
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