N of 1 trials. Practical tools for medication management.
BACKGROUND: In single patient (n of 1) trials, a patient acts as his or her own control in a study comparing the effectiveness of a drug with placebo or another drug. The aim of a single patient trial (SPT) is to identify the best treatment for the individual patient, formalising a 'trial of tr...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
2000
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| _version_ | 1826266535917780992 |
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| author | Nikles, C Glasziou, P Mar, D Duggan, C Mitchell, G |
| author_facet | Nikles, C Glasziou, P Mar, D Duggan, C Mitchell, G |
| author_sort | Nikles, C |
| collection | OXFORD |
| description | BACKGROUND: In single patient (n of 1) trials, a patient acts as his or her own control in a study comparing the effectiveness of a drug with placebo or another drug. The aim of a single patient trial (SPT) is to identify the best treatment for the individual patient, formalising a 'trial of treatment' by using blinding and multiple crossover periods. OBJECTIVE: We have successfully piloted SPTs for osteoarthritis and attention deficit hyperactivity disorder, and several others are currently being piloted. Barriers encountered include: obtaining identical placebos, ethical approval for individual SPTs, standardising doses, determining length of treatment periods, patient withdrawals and cost of the SPTs. DISCUSSION: Only prescribing medications if an individual has been shown to be a responder can greatly benefit general practitioners, patients and the healthcare system. We have established the infrastructure necessary to offer a single patient trial service to GPs and patients anywhere in Australia. This has the potential to revolutionise prescribing for certain chronic conditions. |
| first_indexed | 2024-03-06T20:40:26Z |
| format | Journal article |
| id | oxford-uuid:341a3f49-4a55-4552-b437-46caba598424 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:40:26Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:341a3f49-4a55-4552-b437-46caba5984242022-03-26T13:23:58ZN of 1 trials. Practical tools for medication management.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:341a3f49-4a55-4552-b437-46caba598424EnglishSymplectic Elements at Oxford2000Nikles, CGlasziou, PMar, DDuggan, CMitchell, GBACKGROUND: In single patient (n of 1) trials, a patient acts as his or her own control in a study comparing the effectiveness of a drug with placebo or another drug. The aim of a single patient trial (SPT) is to identify the best treatment for the individual patient, formalising a 'trial of treatment' by using blinding and multiple crossover periods. OBJECTIVE: We have successfully piloted SPTs for osteoarthritis and attention deficit hyperactivity disorder, and several others are currently being piloted. Barriers encountered include: obtaining identical placebos, ethical approval for individual SPTs, standardising doses, determining length of treatment periods, patient withdrawals and cost of the SPTs. DISCUSSION: Only prescribing medications if an individual has been shown to be a responder can greatly benefit general practitioners, patients and the healthcare system. We have established the infrastructure necessary to offer a single patient trial service to GPs and patients anywhere in Australia. This has the potential to revolutionise prescribing for certain chronic conditions. |
| spellingShingle | Nikles, C Glasziou, P Mar, D Duggan, C Mitchell, G N of 1 trials. Practical tools for medication management. |
| title | N of 1 trials. Practical tools for medication management. |
| title_full | N of 1 trials. Practical tools for medication management. |
| title_fullStr | N of 1 trials. Practical tools for medication management. |
| title_full_unstemmed | N of 1 trials. Practical tools for medication management. |
| title_short | N of 1 trials. Practical tools for medication management. |
| title_sort | n of 1 trials practical tools for medication management |
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