Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.

Hypoxia-inducible factor (HIF) is a transcriptional regulator that plays a key role in many aspects of oxygen homeostasis. The heterodimeric HIF complex is regulated by proteolysis of its alpha-subunits, following oxygen-dependent hydroxylation of specific prolyl residues. Although three HIF prolyl...

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Príomhchruthaitheoirí:	Appelhoff, R, Tian, Y, Raval, R, Turley, H, Harris, A, Pugh, C, Ratcliffe, P, Gleadle, J
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	2004

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