Moderate dieting causes 5-HT2C receptor supersensitivity.
Dieting is a widespread behaviour in developed countries, which in predisposed individuals can lead to the development of clinical eating disorders such as bulimia nervosa and anorexia nervosa. We studied the effect of moderate dieting in healthy women on the prolactin response to the serotonin (5-H...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1996
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| _version_ | 1797062096518643712 |
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| author | Cowen, P Clifford, E Walsh, A Williams, C Fairburn, C |
| author_facet | Cowen, P Clifford, E Walsh, A Williams, C Fairburn, C |
| author_sort | Cowen, P |
| collection | OXFORD |
| description | Dieting is a widespread behaviour in developed countries, which in predisposed individuals can lead to the development of clinical eating disorders such as bulimia nervosa and anorexia nervosa. We studied the effect of moderate dieting in healthy women on the prolactin response to the serotonin (5-HT) receptor agonist, m-chlorophenylpiperazine (mCPP), a measure of the sensitivity of post-synaptic 5-HT2C receptors. Dieting significantly increased the prolactin response to mCPP and lowered plasma concentrations of the 5-HT precursor, tryptophan. We propose that dieting in women is associated with the development of functional supersensitivity of 5-HT2C receptors, probably in response to lowered levels of brain 5-HT. Alterations in brain 5-HT neurotransmission could play a part in dieting-induced dysregulation of eating and the development of clinical eating disorders in predisposed individuals. |
| first_indexed | 2024-03-06T20:40:40Z |
| format | Journal article |
| id | oxford-uuid:342bf2e7-717f-4f87-a9da-0f72274d1db3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:40:40Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:342bf2e7-717f-4f87-a9da-0f72274d1db32022-03-26T13:24:23ZModerate dieting causes 5-HT2C receptor supersensitivity.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:342bf2e7-717f-4f87-a9da-0f72274d1db3EnglishSymplectic Elements at Oxford1996Cowen, PClifford, EWalsh, AWilliams, CFairburn, CDieting is a widespread behaviour in developed countries, which in predisposed individuals can lead to the development of clinical eating disorders such as bulimia nervosa and anorexia nervosa. We studied the effect of moderate dieting in healthy women on the prolactin response to the serotonin (5-HT) receptor agonist, m-chlorophenylpiperazine (mCPP), a measure of the sensitivity of post-synaptic 5-HT2C receptors. Dieting significantly increased the prolactin response to mCPP and lowered plasma concentrations of the 5-HT precursor, tryptophan. We propose that dieting in women is associated with the development of functional supersensitivity of 5-HT2C receptors, probably in response to lowered levels of brain 5-HT. Alterations in brain 5-HT neurotransmission could play a part in dieting-induced dysregulation of eating and the development of clinical eating disorders in predisposed individuals. |
| spellingShingle | Cowen, P Clifford, E Walsh, A Williams, C Fairburn, C Moderate dieting causes 5-HT2C receptor supersensitivity. |
| title | Moderate dieting causes 5-HT2C receptor supersensitivity. |
| title_full | Moderate dieting causes 5-HT2C receptor supersensitivity. |
| title_fullStr | Moderate dieting causes 5-HT2C receptor supersensitivity. |
| title_full_unstemmed | Moderate dieting causes 5-HT2C receptor supersensitivity. |
| title_short | Moderate dieting causes 5-HT2C receptor supersensitivity. |
| title_sort | moderate dieting causes 5 ht2c receptor supersensitivity |
| work_keys_str_mv | AT cowenp moderatedietingcauses5ht2creceptorsupersensitivity AT clifforde moderatedietingcauses5ht2creceptorsupersensitivity AT walsha moderatedietingcauses5ht2creceptorsupersensitivity AT williamsc moderatedietingcauses5ht2creceptorsupersensitivity AT fairburnc moderatedietingcauses5ht2creceptorsupersensitivity |