Evolutionary histories and antimicrobial resistance in Shigella flexneri and Shigella sonnei in Southeast Asia
Conventional disease surveillance for shigellosis in developing country settingsrelies on serotyping and low-resolution molecular typing, which fails to contextualise the evolutionary history of the genus. Here, we interrogated a collection of 1,804 Shigella whole genome sequences from organisms iso...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Microbiology Society
2022
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| _version_ | 1797111577142362112 |
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| author | The, HC Bodhidatta, L Pham, DT Mason, CJ Thanh, TH Vinh, PV Turner, P Hem, S Dance, DAB Newton, PN Phetsouvanh, R Davong, V Thwaites, GE Thomson, NR Baker, S Rabaa, MA |
| author_facet | The, HC Bodhidatta, L Pham, DT Mason, CJ Thanh, TH Vinh, PV Turner, P Hem, S Dance, DAB Newton, PN Phetsouvanh, R Davong, V Thwaites, GE Thomson, NR Baker, S Rabaa, MA |
| author_sort | The, HC |
| collection | OXFORD |
| description | Conventional disease surveillance for shigellosis in developing country settingsrelies on serotyping and low-resolution molecular typing, which fails to contextualise the evolutionary history of the genus. Here, we interrogated a collection of 1,804 Shigella whole genome sequences from organisms isolated in four continental Southeast Asian countries (Thailand, Vietnam, Laos, and Cambodia) over three decades to characterise the evolution of both S. flexneri and S. sonnei. We show that S. sonnei and each major S. flexneri serotype are comprised of genetically diverse populations, the majority of which were likely introduced into Southeast Asia in the 1970s-1990s. Intranational and regional dissemination allowed widespread propagation of both species across the region. Our data indicate that the epidemiology of S. sonnei and the major S. flexneri serotypes were characterised by frequent clonal replacement events, coinciding with changing susceptibility patterns against contemporaneous antimicrobials. We conclude that adaptation to antimicrobial pressure was pivotal to the recent evolutionary trajectory of Shigella in Southeast Asia. |
| first_indexed | 2024-03-07T08:12:19Z |
| format | Journal article |
| id | oxford-uuid:3436ee42-063c-49ef-a44f-561d4ce4aa81 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:12:19Z |
| publishDate | 2022 |
| publisher | Microbiology Society |
| record_format | dspace |
| spelling | oxford-uuid:3436ee42-063c-49ef-a44f-561d4ce4aa812023-12-05T13:37:31ZEvolutionary histories and antimicrobial resistance in Shigella flexneri and Shigella sonnei in Southeast AsiaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3436ee42-063c-49ef-a44f-561d4ce4aa81EnglishSymplectic ElementsMicrobiology Society2022The, HCBodhidatta, LPham, DTMason, CJThanh, THVinh, PVTurner, PHem, SDance, DABNewton, PNPhetsouvanh, RDavong, VThwaites, GEThomson, NRBaker, SRabaa, MAConventional disease surveillance for shigellosis in developing country settingsrelies on serotyping and low-resolution molecular typing, which fails to contextualise the evolutionary history of the genus. Here, we interrogated a collection of 1,804 Shigella whole genome sequences from organisms isolated in four continental Southeast Asian countries (Thailand, Vietnam, Laos, and Cambodia) over three decades to characterise the evolution of both S. flexneri and S. sonnei. We show that S. sonnei and each major S. flexneri serotype are comprised of genetically diverse populations, the majority of which were likely introduced into Southeast Asia in the 1970s-1990s. Intranational and regional dissemination allowed widespread propagation of both species across the region. Our data indicate that the epidemiology of S. sonnei and the major S. flexneri serotypes were characterised by frequent clonal replacement events, coinciding with changing susceptibility patterns against contemporaneous antimicrobials. We conclude that adaptation to antimicrobial pressure was pivotal to the recent evolutionary trajectory of Shigella in Southeast Asia. |
| spellingShingle | The, HC Bodhidatta, L Pham, DT Mason, CJ Thanh, TH Vinh, PV Turner, P Hem, S Dance, DAB Newton, PN Phetsouvanh, R Davong, V Thwaites, GE Thomson, NR Baker, S Rabaa, MA Evolutionary histories and antimicrobial resistance in Shigella flexneri and Shigella sonnei in Southeast Asia |
| title | Evolutionary histories and antimicrobial resistance in Shigella flexneri and Shigella sonnei in Southeast Asia |
| title_full | Evolutionary histories and antimicrobial resistance in Shigella flexneri and Shigella sonnei in Southeast Asia |
| title_fullStr | Evolutionary histories and antimicrobial resistance in Shigella flexneri and Shigella sonnei in Southeast Asia |
| title_full_unstemmed | Evolutionary histories and antimicrobial resistance in Shigella flexneri and Shigella sonnei in Southeast Asia |
| title_short | Evolutionary histories and antimicrobial resistance in Shigella flexneri and Shigella sonnei in Southeast Asia |
| title_sort | evolutionary histories and antimicrobial resistance in shigella flexneri and shigella sonnei in southeast asia |
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