Modelling multiscale aspects of colorectal cancer
Colorectal cancer (CRC) is responsible for nearly half a million deaths annually world-wide [11]. We present a series of mathematical models describing the dynamics of the intestinal epithelium and the kinetics of the molecular pathway most commonly mutated in CRC, the Wnt signalling network. We als...
| Main Authors: | , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
2007
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| _version_ | 1826266562058780672 |
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| author | Van Leeuwen, I Byrne, H Johnston, MD Edwards, C Chapman, S Bodmer, W Maini, P |
| author_facet | Van Leeuwen, I Byrne, H Johnston, MD Edwards, C Chapman, S Bodmer, W Maini, P |
| author_sort | Van Leeuwen, I |
| collection | OXFORD |
| description | Colorectal cancer (CRC) is responsible for nearly half a million deaths annually world-wide [11]. We present a series of mathematical models describing the dynamics of the intestinal epithelium and the kinetics of the molecular pathway most commonly mutated in CRC, the Wnt signalling network. We also discuss how we are coupling such models to build a multiscale model of normal and aberrant guts. This will enable us to combine disparate experimental and clinical data, to investigate interactions between phenomena taking place at different levels of organisation and, eventually, to test the efficacy of new drugs on the system as a whole. © 2008 American Institute of Physics. |
| first_indexed | 2024-03-06T20:40:50Z |
| format | Journal article |
| id | oxford-uuid:343a0215-3262-4b98-bec7-2bb71e27cab4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:40:50Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:343a0215-3262-4b98-bec7-2bb71e27cab42022-03-26T13:24:44ZModelling multiscale aspects of colorectal cancerJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:343a0215-3262-4b98-bec7-2bb71e27cab4EnglishSymplectic Elements at Oxford2007Van Leeuwen, IByrne, HJohnston, MDEdwards, CChapman, SBodmer, WMaini, PColorectal cancer (CRC) is responsible for nearly half a million deaths annually world-wide [11]. We present a series of mathematical models describing the dynamics of the intestinal epithelium and the kinetics of the molecular pathway most commonly mutated in CRC, the Wnt signalling network. We also discuss how we are coupling such models to build a multiscale model of normal and aberrant guts. This will enable us to combine disparate experimental and clinical data, to investigate interactions between phenomena taking place at different levels of organisation and, eventually, to test the efficacy of new drugs on the system as a whole. © 2008 American Institute of Physics. |
| spellingShingle | Van Leeuwen, I Byrne, H Johnston, MD Edwards, C Chapman, S Bodmer, W Maini, P Modelling multiscale aspects of colorectal cancer |
| title | Modelling multiscale aspects of colorectal cancer |
| title_full | Modelling multiscale aspects of colorectal cancer |
| title_fullStr | Modelling multiscale aspects of colorectal cancer |
| title_full_unstemmed | Modelling multiscale aspects of colorectal cancer |
| title_short | Modelling multiscale aspects of colorectal cancer |
| title_sort | modelling multiscale aspects of colorectal cancer |
| work_keys_str_mv | AT vanleeuweni modellingmultiscaleaspectsofcolorectalcancer AT byrneh modellingmultiscaleaspectsofcolorectalcancer AT johnstonmd modellingmultiscaleaspectsofcolorectalcancer AT edwardsc modellingmultiscaleaspectsofcolorectalcancer AT chapmans modellingmultiscaleaspectsofcolorectalcancer AT bodmerw modellingmultiscaleaspectsofcolorectalcancer AT mainip modellingmultiscaleaspectsofcolorectalcancer |