Physical activity and gain in abdominal adiposity and body weight: prospective cohort study in 288,498 men and women.
BACKGROUND: The protective effect of physical activity (PA) on abdominal adiposity is unclear. OBJECTIVE: We examined whether PA independently predicted gains in body weight and abdominal adiposity. DESIGN: In a prospective cohort study [the EPIC (European Prospective Investigation into Cancer and N...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2011
|
| _version_ | 1797062115431809024 |
|---|---|
| author | Ekelund, U Besson, H Luan, J May, A Sharp, S Brage, S Travier, N Agudo, A Slimani, N Rinaldi, S Jenab, M Norat, T Mouw, T Rohrmann, S Kaaks, R Bergmann, M Boeing, H Clavel-Chapelon, F Boutron-Ruault, M Overvad, K Jakobsen, M Johnsen, N Halkjaer, J Gonzalez, C Rodriguez, L |
| author_facet | Ekelund, U Besson, H Luan, J May, A Sharp, S Brage, S Travier, N Agudo, A Slimani, N Rinaldi, S Jenab, M Norat, T Mouw, T Rohrmann, S Kaaks, R Bergmann, M Boeing, H Clavel-Chapelon, F Boutron-Ruault, M Overvad, K Jakobsen, M Johnsen, N Halkjaer, J Gonzalez, C Rodriguez, L |
| author_sort | Ekelund, U |
| collection | OXFORD |
| description | BACKGROUND: The protective effect of physical activity (PA) on abdominal adiposity is unclear. OBJECTIVE: We examined whether PA independently predicted gains in body weight and abdominal adiposity. DESIGN: In a prospective cohort study [the EPIC (European Prospective Investigation into Cancer and Nutrition)], we followed 84,511 men and 203,987 women for 5.1 y. PA was assessed by a validated questionnaire, and individuals were categorized into 4 groups (inactive, moderately inactive, moderately active, and active). Body weight and waist circumference were measured at baseline and self-reported at follow-up. We used multilevel mixed-effects linear regression models and stratified our analyses by sex with adjustments for age, smoking status, alcohol consumption, educational level, total energy intake, duration of follow-up, baseline body weight, change in body weight, and waist circumference (when applicable). RESULTS: PA significantly predicted a lower waist circumference (in cm) in men (β = -0.045; 95% CI: -0.057, -0.034) and in women (β = -0.035; 95% CI: -0.056, -0.015) independent of baseline body weight, baseline waist circumference, and other confounding factors. The magnitude of associations was materially unchanged after adjustment for change in body weight. PA was not significantly associated with annual weight gain (in kg) in men (β = -0.008; 95% CI: -0.02, 0.003) and women (β = -0.01; 95% CI: -0.02, 0.0006). The odds of becoming obese were reduced by 7% (P < 0.001) and 10% (P < 0.001) for a one-category difference in baseline PA in men and women, respectively. CONCLUSION: Our results suggest that a higher level of PA reduces abdominal adiposity independent of baseline and changes in body weight and is thus a useful strategy for preventing chronic diseases and premature deaths. |
| first_indexed | 2024-03-06T20:40:57Z |
| format | Journal article |
| id | oxford-uuid:34434d86-6880-402e-b650-2aa8139045ae |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:40:57Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:34434d86-6880-402e-b650-2aa8139045ae2022-03-26T13:24:58ZPhysical activity and gain in abdominal adiposity and body weight: prospective cohort study in 288,498 men and women.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:34434d86-6880-402e-b650-2aa8139045aeEnglishSymplectic Elements at Oxford2011Ekelund, UBesson, HLuan, JMay, ASharp, SBrage, STravier, NAgudo, ASlimani, NRinaldi, SJenab, MNorat, TMouw, TRohrmann, SKaaks, RBergmann, MBoeing, HClavel-Chapelon, FBoutron-Ruault, MOvervad, KJakobsen, MJohnsen, NHalkjaer, JGonzalez, CRodriguez, LBACKGROUND: The protective effect of physical activity (PA) on abdominal adiposity is unclear. OBJECTIVE: We examined whether PA independently predicted gains in body weight and abdominal adiposity. DESIGN: In a prospective cohort study [the EPIC (European Prospective Investigation into Cancer and Nutrition)], we followed 84,511 men and 203,987 women for 5.1 y. PA was assessed by a validated questionnaire, and individuals were categorized into 4 groups (inactive, moderately inactive, moderately active, and active). Body weight and waist circumference were measured at baseline and self-reported at follow-up. We used multilevel mixed-effects linear regression models and stratified our analyses by sex with adjustments for age, smoking status, alcohol consumption, educational level, total energy intake, duration of follow-up, baseline body weight, change in body weight, and waist circumference (when applicable). RESULTS: PA significantly predicted a lower waist circumference (in cm) in men (β = -0.045; 95% CI: -0.057, -0.034) and in women (β = -0.035; 95% CI: -0.056, -0.015) independent of baseline body weight, baseline waist circumference, and other confounding factors. The magnitude of associations was materially unchanged after adjustment for change in body weight. PA was not significantly associated with annual weight gain (in kg) in men (β = -0.008; 95% CI: -0.02, 0.003) and women (β = -0.01; 95% CI: -0.02, 0.0006). The odds of becoming obese were reduced by 7% (P < 0.001) and 10% (P < 0.001) for a one-category difference in baseline PA in men and women, respectively. CONCLUSION: Our results suggest that a higher level of PA reduces abdominal adiposity independent of baseline and changes in body weight and is thus a useful strategy for preventing chronic diseases and premature deaths. |
| spellingShingle | Ekelund, U Besson, H Luan, J May, A Sharp, S Brage, S Travier, N Agudo, A Slimani, N Rinaldi, S Jenab, M Norat, T Mouw, T Rohrmann, S Kaaks, R Bergmann, M Boeing, H Clavel-Chapelon, F Boutron-Ruault, M Overvad, K Jakobsen, M Johnsen, N Halkjaer, J Gonzalez, C Rodriguez, L Physical activity and gain in abdominal adiposity and body weight: prospective cohort study in 288,498 men and women. |
| title | Physical activity and gain in abdominal adiposity and body weight: prospective cohort study in 288,498 men and women. |
| title_full | Physical activity and gain in abdominal adiposity and body weight: prospective cohort study in 288,498 men and women. |
| title_fullStr | Physical activity and gain in abdominal adiposity and body weight: prospective cohort study in 288,498 men and women. |
| title_full_unstemmed | Physical activity and gain in abdominal adiposity and body weight: prospective cohort study in 288,498 men and women. |
| title_short | Physical activity and gain in abdominal adiposity and body weight: prospective cohort study in 288,498 men and women. |
| title_sort | physical activity and gain in abdominal adiposity and body weight prospective cohort study in 288 498 men and women |
| work_keys_str_mv | AT ekelundu physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT bessonh physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT luanj physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT maya physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT sharps physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT brages physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT traviern physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT agudoa physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT slimanin physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT rinaldis physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT jenabm physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT noratt physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT mouwt physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT rohrmanns physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT kaaksr physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT bergmannm physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT boeingh physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT clavelchapelonf physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT boutronruaultm physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT overvadk physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT jakobsenm physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT johnsenn physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT halkjaerj physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT gonzalezc physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen AT rodriguezl physicalactivityandgaininabdominaladiposityandbodyweightprospectivecohortstudyin288498menandwomen |