Immune responses to adenoviral vectors during gene transfer in the brain.

Immune responses to adenoviral vectors during gene transfer in the brain.

We have investigated the immune response to E1-deleted adenovirus vectors encoding the lacZ gene introduced into the brains of adult mice. Injection of these nonreplicating vectors caused a marked inflammatory response in the brain as assessed by immunocytochemistry and flow cytometry of leukocytes....

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Bibliographic Details
Main Authors:	Kajiwara, K, Byrnes, A, Charlton, H, Wood, M, Wood, K
Format:	Journal article
Language:	English
Published:	1997

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