Escape from HLA-B*08-restricted CD8 T cells by hepatitis C virus is associated with fitness costs.

Escape from HLA-B*08-restricted CD8 T cells by hepatitis C virus is associated with fitness costs.

The inherent sequence diversity of the hepatitis C virus (HCV) represents a major hurdle for the adaptive immune system to control viral replication. Mutational escape within targeted CD8 epitopes during acute HCV infection has been well documented and is one possible mechanism for T-cell failure. H...

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Príomhchruthaitheoirí: Salloum, S, Oniangue-Ndza, C, Neumann-Haefelin, C, Hudson, L, Giugliano, S, aus dem Siepen, M, Nattermann, J, Spengler, U, Lauer, G, Wiese, M, Klenerman, P, Bright, H, Scherbaum, N, Thimme, R, Roggendorf, M, Viazov, S, Timm, J
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2008

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