5,6-Dihydrothymine impairs the base excision repair pathway of a closely opposed AP site or single-strand break.
Ionizing radiation can induce clustered DNA damage (two or more lesions formed within one to two helical turns of DNA by passage of a single ionization track). Using oligonucleotide constructs containing clustered DNA lesions at defined positions, evidence is presented demonstrating that a persisten...
Հիմնական հեղինակներ: | Byrne, S, Cunniffe, S, O'Neill, P, Lomax, M |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
2009
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Նմանատիպ նյութեր
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Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency.
: Mourgues, S, և այլն
Հրապարակվել է: (2007) -
8-OxoG retards the activity of the ligase III/XRCC1 complex during the repair of a single-strand break, when present within a clustered DNA damage site.
: Lomax, M, և այլն
Հրապարակվել է: (2004) -
Interplay of two major repair pathways in the processing of complex double-strand DNA breaks.
: Dobbs, T, և այլն
Հրապարակվել է: (2008) -
8-OxoA inhibits the incision of an AP site by the DNA glycosylases Fpg, Nth and the AP endonuclease HAP1.
: Lomax, M, և այլն
Հրապարակվել է: (2005) -
Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage.
: Eccles, L, և այլն
Հրապարակվել է: (2010)