A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors.

A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors.

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Histone deacetylase (HDAC) is an emergent anticancer target, and HR23B is a biomarker for response to HDAC inhibitors. We show here that HR23B has impacts on two documented effects of HDAC inhibitors; HDAC inhibitors cause apoptosis in cells expressing high levels of HR23B, whereas in cells with low...

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Bibliographic Details
Main Authors: New, M, Olzscha, H, Liu, G, Khan, O, Stimson, L, McGouran, J, Kerr, D, Coutts, A, Kessler, B, Middleton, M, La Thangue, N
Format: Journal article
Language:English
Published: 2013

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