c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent.
c-erbB-2-positive breast carcinomas are highly aggressive tumors. In vitro data on breast cell lines showed that c-erbB-2 enhanced translational efficiency of hypoxia inducible factor-1alpha (HIF1alpha) production (Laughner et al., Mol Cell Biol 2001;21:3995-4005). We investigated the clinical corre...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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| _version_ | 1797062202756169728 |
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| author | Giatromanolaki, A Koukourakis, M Simopoulos, C Polychronidis, A Gatter, K Harris, A Sivridis, E |
| author_facet | Giatromanolaki, A Koukourakis, M Simopoulos, C Polychronidis, A Gatter, K Harris, A Sivridis, E |
| author_sort | Giatromanolaki, A |
| collection | OXFORD |
| description | c-erbB-2-positive breast carcinomas are highly aggressive tumors. In vitro data on breast cell lines showed that c-erbB-2 enhanced translational efficiency of hypoxia inducible factor-1alpha (HIF1alpha) production (Laughner et al., Mol Cell Biol 2001;21:3995-4005). We investigated the clinical correlate of this observation to assess whether c-erbB-2 expression was related to HIF1alpha expression, angiogenesis, and prognosis. A series of 180 breast carcinomas of known c-erbB-2 status (90 c-erbB-2-positive and 90 c-erbB-2-negative carcinomas) were stained immunohistochemically for HIF1alpha and CD31 endothelial cell antigen. c-erbB-2 positivity was clearly related to HIF1alpha protein expression and high angiogenesis. However, prognosis was decreased only in cases with simultaneous c-erbB-2 and HIF1alpha expression. If activation of c-erbB-2 in humans results in overexpression of HIF1alpha independently of conditions of hypoxia, as occur in experimental studies, this interaction may represent a main pathway conferring clinical aggressiveness to c-erbB-2-positive breast tumors. |
| first_indexed | 2024-03-06T20:42:08Z |
| format | Journal article |
| id | oxford-uuid:34a36491-801c-46ab-9fc5-ad108f777351 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:42:08Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:34a36491-801c-46ab-9fc5-ad108f7773512022-03-26T13:27:12Zc-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:34a36491-801c-46ab-9fc5-ad108f777351EnglishSymplectic Elements at Oxford2004Giatromanolaki, AKoukourakis, MSimopoulos, CPolychronidis, AGatter, KHarris, ASivridis, Ec-erbB-2-positive breast carcinomas are highly aggressive tumors. In vitro data on breast cell lines showed that c-erbB-2 enhanced translational efficiency of hypoxia inducible factor-1alpha (HIF1alpha) production (Laughner et al., Mol Cell Biol 2001;21:3995-4005). We investigated the clinical correlate of this observation to assess whether c-erbB-2 expression was related to HIF1alpha expression, angiogenesis, and prognosis. A series of 180 breast carcinomas of known c-erbB-2 status (90 c-erbB-2-positive and 90 c-erbB-2-negative carcinomas) were stained immunohistochemically for HIF1alpha and CD31 endothelial cell antigen. c-erbB-2 positivity was clearly related to HIF1alpha protein expression and high angiogenesis. However, prognosis was decreased only in cases with simultaneous c-erbB-2 and HIF1alpha expression. If activation of c-erbB-2 in humans results in overexpression of HIF1alpha independently of conditions of hypoxia, as occur in experimental studies, this interaction may represent a main pathway conferring clinical aggressiveness to c-erbB-2-positive breast tumors. |
| spellingShingle | Giatromanolaki, A Koukourakis, M Simopoulos, C Polychronidis, A Gatter, K Harris, A Sivridis, E c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent. |
| title | c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent. |
| title_full | c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent. |
| title_fullStr | c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent. |
| title_full_unstemmed | c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent. |
| title_short | c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent. |
| title_sort | c erbb 2 related aggressiveness in breast cancer is hypoxia inducible factor 1alpha dependent |
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