Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.
A good fit: Interactions between A-kinase anchoring proteins (AKAPs) and protein kinaseA (PKA) play key roles in a plethora of physiologically relevant processes whose dysregulation causes or is associated with diseases such as heart failure. Terpyridines have been developed as α-helix mimetics for...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2013
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| _version_ | 1797062203829911552 |
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| author | Schäfer, G Milić, J Eldahshan, A Götz, F Zühlke, K Schillinger, C Kreuchwig, A Elkins, J Abdul Azeez, K Oder, A Moutty, M Masada, N Beerbaum, M Schlegel, B Niquet, S Schmieder, P Krause, G von Kries, J Cooper, D Knapp, S Rademann, J Rosenthal, W Klussmann, E |
| author_facet | Schäfer, G Milić, J Eldahshan, A Götz, F Zühlke, K Schillinger, C Kreuchwig, A Elkins, J Abdul Azeez, K Oder, A Moutty, M Masada, N Beerbaum, M Schlegel, B Niquet, S Schmieder, P Krause, G von Kries, J Cooper, D Knapp, S Rademann, J Rosenthal, W Klussmann, E |
| author_sort | Schäfer, G |
| collection | OXFORD |
| description | A good fit: Interactions between A-kinase anchoring proteins (AKAPs) and protein kinaseA (PKA) play key roles in a plethora of physiologically relevant processes whose dysregulation causes or is associated with diseases such as heart failure. Terpyridines have been developed as α-helix mimetics for the inhibition of such interactions and are the first biologically active, nonpeptidic compounds that block the AKAP binding site of PKA. © 2013 The Authors. Published by Wiley-VCH Verlag GmbH and Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| first_indexed | 2024-03-06T20:42:09Z |
| format | Journal article |
| id | oxford-uuid:34a445e1-dfb6-4070-86da-e67d6a4d4a52 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:42:09Z |
| publishDate | 2013 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:34a445e1-dfb6-4070-86da-e67d6a4d4a522022-03-26T13:27:25ZHighly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:34a445e1-dfb6-4070-86da-e67d6a4d4a52EnglishSymplectic Elements at OxfordWiley2013Schäfer, GMilić, JEldahshan, AGötz, FZühlke, KSchillinger, CKreuchwig, AElkins, JAbdul Azeez, KOder, AMoutty, MMasada, NBeerbaum, MSchlegel, BNiquet, SSchmieder, PKrause, Gvon Kries, JCooper, DKnapp, SRademann, JRosenthal, WKlussmann, EA good fit: Interactions between A-kinase anchoring proteins (AKAPs) and protein kinaseA (PKA) play key roles in a plethora of physiologically relevant processes whose dysregulation causes or is associated with diseases such as heart failure. Terpyridines have been developed as α-helix mimetics for the inhibition of such interactions and are the first biologically active, nonpeptidic compounds that block the AKAP binding site of PKA. © 2013 The Authors. Published by Wiley-VCH Verlag GmbH and Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Schäfer, G Milić, J Eldahshan, A Götz, F Zühlke, K Schillinger, C Kreuchwig, A Elkins, J Abdul Azeez, K Oder, A Moutty, M Masada, N Beerbaum, M Schlegel, B Niquet, S Schmieder, P Krause, G von Kries, J Cooper, D Knapp, S Rademann, J Rosenthal, W Klussmann, E Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions. |
| title | Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions. |
| title_full | Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions. |
| title_fullStr | Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions. |
| title_full_unstemmed | Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions. |
| title_short | Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions. |
| title_sort | highly functionalized terpyridines as competitive inhibitors of akap pka interactions |
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