Choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial - the development of the DELTA2 guidance

Choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial - the development of the DELTA2 guidance

<h4>Background</h4> <p>A key step in the design of a randomised controlled trial is the estimation of the number of participants needed. The most common approach is to specify a target difference in the primary outcome between the randomised groups and then estimate the correspond...

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Main Authors: Sones, WR, Julious, SA, Rothwell, J, Ramsay, C, Hampson, L, Emsley, R, Walters, S, Hewitt, C, Bland, M, Fergusson, D, Berlin, J, Altman, D, Vale, L, Cook, JA
Format: Journal article
Published: BioMed Central 2018

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