Mefloquine in infants and young children.
In an area where multi-drug resistance in Plasmodium falciparum is a particular problem, more than 500 children under 5 years of age weighing > 5 kg were treated with mefloquine, either alone or combined with an artemisinin derivative, and followed up for a minimum of 28 days. The principal a...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1996
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| _version_ | 1826266668634996736 |
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| author | Luxemburger, C Price, R Nosten, F Ter Kuile, F Chongsuphajaisiddhi, T White, N |
| author_facet | Luxemburger, C Price, R Nosten, F Ter Kuile, F Chongsuphajaisiddhi, T White, N |
| author_sort | Luxemburger, C |
| collection | OXFORD |
| description | In an area where multi-drug resistance in Plasmodium falciparum is a particular problem, more than 500 children under 5 years of age weighing > 5 kg were treated with mefloquine, either alone or combined with an artemisinin derivative, and followed up for a minimum of 28 days. The principal adverse effect was vomiting and this was associated with reduced efficacy of treatment (even when treatment was repeated). Later adverse effects occurred less frequently than in adults. There was no serious toxicity and, in particular, there were no neuropsychiatric side-effects. The high dose of mefloquine (25 mg/kg) required in this area is well tolerated by young children. It should be given in a divided dose of 15 mg/kg initially, followed by 10 mg/kg > or = 12 hours later. |
| first_indexed | 2024-03-06T20:42:26Z |
| format | Journal article |
| id | oxford-uuid:34b8e413-8300-4d11-b916-bbd824e1d8b5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:42:26Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:34b8e413-8300-4d11-b916-bbd824e1d8b52022-03-26T13:27:46ZMefloquine in infants and young children.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:34b8e413-8300-4d11-b916-bbd824e1d8b5EnglishSymplectic Elements at Oxford1996Luxemburger, CPrice, RNosten, FTer Kuile, FChongsuphajaisiddhi, TWhite, NIn an area where multi-drug resistance in Plasmodium falciparum is a particular problem, more than 500 children under 5 years of age weighing > 5 kg were treated with mefloquine, either alone or combined with an artemisinin derivative, and followed up for a minimum of 28 days. The principal adverse effect was vomiting and this was associated with reduced efficacy of treatment (even when treatment was repeated). Later adverse effects occurred less frequently than in adults. There was no serious toxicity and, in particular, there were no neuropsychiatric side-effects. The high dose of mefloquine (25 mg/kg) required in this area is well tolerated by young children. It should be given in a divided dose of 15 mg/kg initially, followed by 10 mg/kg > or = 12 hours later. |
| spellingShingle | Luxemburger, C Price, R Nosten, F Ter Kuile, F Chongsuphajaisiddhi, T White, N Mefloquine in infants and young children. |
| title | Mefloquine in infants and young children. |
| title_full | Mefloquine in infants and young children. |
| title_fullStr | Mefloquine in infants and young children. |
| title_full_unstemmed | Mefloquine in infants and young children. |
| title_short | Mefloquine in infants and young children. |
| title_sort | mefloquine in infants and young children |
| work_keys_str_mv | AT luxemburgerc mefloquineininfantsandyoungchildren AT pricer mefloquineininfantsandyoungchildren AT nostenf mefloquineininfantsandyoungchildren AT terkuilef mefloquineininfantsandyoungchildren AT chongsuphajaisiddhit mefloquineininfantsandyoungchildren AT whiten mefloquineininfantsandyoungchildren |