Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations.
Increased levels of vitamin D and calcium may play a protective role in colorectal cancer (CRC) risk. It has been suggested that these effects may be mediated by genetic variants of the vitamin D receptor (VDR) and the calcium sensing receptor (CASR). However, current epidemiologic evidence from Eur...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2009
|
| _version_ | 1826266677660090368 |
|---|---|
| author | Jenab, M McKay, J Bueno-de-Mesquita, H van Duijnhoven, F Ferrari, P Slimani, N Jansen, E Pischon, T Rinaldi, S Tjønneland, A Olsen, A Overvad, K Boutron-Ruault, M Clavel-Chapelon, F Engel, P Kaaks, R Linseisen, J Boeing, H Fisher, E Trichopoulou, A Dilis, V Oustoglou, E Berrino, F Vineis, P Mattiello, A |
| author_facet | Jenab, M McKay, J Bueno-de-Mesquita, H van Duijnhoven, F Ferrari, P Slimani, N Jansen, E Pischon, T Rinaldi, S Tjønneland, A Olsen, A Overvad, K Boutron-Ruault, M Clavel-Chapelon, F Engel, P Kaaks, R Linseisen, J Boeing, H Fisher, E Trichopoulou, A Dilis, V Oustoglou, E Berrino, F Vineis, P Mattiello, A |
| author_sort | Jenab, M |
| collection | OXFORD |
| description | Increased levels of vitamin D and calcium may play a protective role in colorectal cancer (CRC) risk. It has been suggested that these effects may be mediated by genetic variants of the vitamin D receptor (VDR) and the calcium sensing receptor (CASR). However, current epidemiologic evidence from European populations for a role of these genes in CRC risk is scarce. In addition, it is not clear whether these genes may modulate CRC risk independently or by interaction with blood vitamin D concentration and level of dietary calcium intake. A case-control study was conducted nested within the European Prospective Investigation into Cancer and Nutrition. CRC cases (1,248) were identified and matched to 1,248 control subjects. Genotyping for the VDR (BsmI: rs1544410; Fok1: rs2228570) and CASR (rs1801725) genes was done by Taqman, and serum vitamin D (25OHD) concentrations were measured. Conditional logistic regression was used to estimate the incidence rate ratio (RR). Compared with the wild-type bb, the BB genotype of the VDR BsmI polymorphism was associated with a reduced risk of CRC [RR, 0.76; 95% confidence interval (CI), 0.59-0.98). The association was observed for colon cancer (RR, 0.69; 95% CI, 0.45-0.95) but not rectal cancer (RR, 0.97; 95% CI, 0.62-1.49). The Fok1 and CASR genotypes were not associated with CRC risk in this study. No interactions were noted for any of the polymorphisms with serum 25OHD concentration or level of dietary calcium. These results confirm a role for the BsmI polymorphism of the VDR gene in CRC risk, independent of serum 25OHD concentration and dietary calcium intake. |
| first_indexed | 2024-03-06T20:42:35Z |
| format | Journal article |
| id | oxford-uuid:34c2a0e7-cfc7-4bb7-bf97-40a0f1896d13 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:42:35Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:34c2a0e7-cfc7-4bb7-bf97-40a0f1896d132022-03-26T13:28:05ZVitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:34c2a0e7-cfc7-4bb7-bf97-40a0f1896d13EnglishSymplectic Elements at Oxford2009Jenab, MMcKay, JBueno-de-Mesquita, Hvan Duijnhoven, FFerrari, PSlimani, NJansen, EPischon, TRinaldi, STjønneland, AOlsen, AOvervad, KBoutron-Ruault, MClavel-Chapelon, FEngel, PKaaks, RLinseisen, JBoeing, HFisher, ETrichopoulou, ADilis, VOustoglou, EBerrino, FVineis, PMattiello, AIncreased levels of vitamin D and calcium may play a protective role in colorectal cancer (CRC) risk. It has been suggested that these effects may be mediated by genetic variants of the vitamin D receptor (VDR) and the calcium sensing receptor (CASR). However, current epidemiologic evidence from European populations for a role of these genes in CRC risk is scarce. In addition, it is not clear whether these genes may modulate CRC risk independently or by interaction with blood vitamin D concentration and level of dietary calcium intake. A case-control study was conducted nested within the European Prospective Investigation into Cancer and Nutrition. CRC cases (1,248) were identified and matched to 1,248 control subjects. Genotyping for the VDR (BsmI: rs1544410; Fok1: rs2228570) and CASR (rs1801725) genes was done by Taqman, and serum vitamin D (25OHD) concentrations were measured. Conditional logistic regression was used to estimate the incidence rate ratio (RR). Compared with the wild-type bb, the BB genotype of the VDR BsmI polymorphism was associated with a reduced risk of CRC [RR, 0.76; 95% confidence interval (CI), 0.59-0.98). The association was observed for colon cancer (RR, 0.69; 95% CI, 0.45-0.95) but not rectal cancer (RR, 0.97; 95% CI, 0.62-1.49). The Fok1 and CASR genotypes were not associated with CRC risk in this study. No interactions were noted for any of the polymorphisms with serum 25OHD concentration or level of dietary calcium. These results confirm a role for the BsmI polymorphism of the VDR gene in CRC risk, independent of serum 25OHD concentration and dietary calcium intake. |
| spellingShingle | Jenab, M McKay, J Bueno-de-Mesquita, H van Duijnhoven, F Ferrari, P Slimani, N Jansen, E Pischon, T Rinaldi, S Tjønneland, A Olsen, A Overvad, K Boutron-Ruault, M Clavel-Chapelon, F Engel, P Kaaks, R Linseisen, J Boeing, H Fisher, E Trichopoulou, A Dilis, V Oustoglou, E Berrino, F Vineis, P Mattiello, A Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. |
| title | Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. |
| title_full | Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. |
| title_fullStr | Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. |
| title_full_unstemmed | Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. |
| title_short | Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. |
| title_sort | vitamin d receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in european populations |
| work_keys_str_mv | AT jenabm vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT mckayj vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT buenodemesquitah vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT vanduijnhovenf vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT ferrarip vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT slimanin vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT jansene vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT pischont vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT rinaldis vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT tjønnelanda vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT olsena vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT overvadk vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT boutronruaultm vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT clavelchapelonf vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT engelp vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT kaaksr vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT linseisenj vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT boeingh vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT fishere vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT trichopouloua vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT dilisv vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT oustogloue vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT berrinof vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT vineisp vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations AT mattielloa vitamindreceptorandcalciumsensingreceptorpolymorphismsandtheriskofcolorectalcancerineuropeanpopulations |