Erythroferrone inhibits the induction of hepcidin by BMP6

Erythroferrone inhibits the induction of hepcidin by BMP6

Decreased hepcidin mobilizes iron, which facilitates erythropoiesis, but excess iron is pathogenic in beta-thalassemia. Erythropoietin (EPO) enhances erythroferrone (ERFE) synthesis by erythroblasts, and ERFE suppresses hepatic hepcidin production, through an unknown mechanism. The BMP/SMAD pathway...

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Main Authors: Arezes, J, Foy, N, McHugh, K, Sawant, A, Quinkert, D, Terraube, V, Brinth, A, Tam, M, Lavallie, E, Taylor, S, Armitage, A, Pasricha, S, Cunningham, O, Lambert, M, Draper, S, Jasuja, R, Drakesmith, H
Format: Journal article
Language:English
Published: American Society of Hematology 2018

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