Structure of prolyl-tRNA synthetase-halofuginone complex provides basis for development of drugs against malaria and toxoplasmosis

Structure of prolyl-tRNA synthetase-halofuginone complex provides basis for development of drugs against malaria and toxoplasmosis

The Chinese herb Dichroa febrifuga has traditionally treated malaria-associated fever. Its active component febrifugine (FF) and derivatives such as halofuginone (HF) are potent anti-malarials. Here, we show that FF-based derivatives arrest parasite growth by direct interaction with and inhibition o...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak: Jain, V, Yogavel, M, Oshima, Y, Kikuchi, H, Touquet, B, Hakimi, M, Sharma, A
Formatua: Journal article
Argitaratua: Cell Press 2015

Antzeko izenburuak

Antzeko izenburuak