Structure of prolyl-tRNA synthetase-halofuginone complex provides basis for development of drugs against malaria and toxoplasmosis

Structure of prolyl-tRNA synthetase-halofuginone complex provides basis for development of drugs against malaria and toxoplasmosis

The Chinese herb Dichroa febrifuga has traditionally treated malaria-associated fever. Its active component febrifugine (FF) and derivatives such as halofuginone (HF) are potent anti-malarials. Here, we show that FF-based derivatives arrest parasite growth by direct interaction with and inhibition o...

书目详细资料
Main Authors:	Jain, V, Yogavel, M, Oshima, Y, Kikuchi, H, Touquet, B, Hakimi, M, Sharma, A
格式:	Journal article
出版:	Cell Press 2015

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