Lithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression.
The addition of lithium to the tricyclic antidepressant medication of 11 depressed patients resulted in an increase in the prolactin response to L-tryptophan after both 4 days and 4 weeks of lithium treatment. There was also a significant fall in Hamilton Depression scores. The results suggest that...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1989
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| _version_ | 1797062247030194176 |
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| author | Cowen, P McCance, S Cohen, P Julier, D |
| author_facet | Cowen, P McCance, S Cohen, P Julier, D |
| author_sort | Cowen, P |
| collection | OXFORD |
| description | The addition of lithium to the tricyclic antidepressant medication of 11 depressed patients resulted in an increase in the prolactin response to L-tryptophan after both 4 days and 4 weeks of lithium treatment. There was also a significant fall in Hamilton Depression scores. The results suggest that lithium and tricyclic antidepressants may act synergistically to enhance certain aspects of brain 5-HT function in depressed patients. |
| first_indexed | 2024-03-06T20:42:47Z |
| format | Journal article |
| id | oxford-uuid:34cfda1f-d88e-41ca-a8fc-6161836dda53 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:42:47Z |
| publishDate | 1989 |
| record_format | dspace |
| spelling | oxford-uuid:34cfda1f-d88e-41ca-a8fc-6161836dda532022-03-26T13:28:27ZLithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:34cfda1f-d88e-41ca-a8fc-6161836dda53EnglishSymplectic Elements at Oxford1989Cowen, PMcCance, SCohen, PJulier, DThe addition of lithium to the tricyclic antidepressant medication of 11 depressed patients resulted in an increase in the prolactin response to L-tryptophan after both 4 days and 4 weeks of lithium treatment. There was also a significant fall in Hamilton Depression scores. The results suggest that lithium and tricyclic antidepressants may act synergistically to enhance certain aspects of brain 5-HT function in depressed patients. |
| spellingShingle | Cowen, P McCance, S Cohen, P Julier, D Lithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression. |
| title | Lithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression. |
| title_full | Lithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression. |
| title_fullStr | Lithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression. |
| title_full_unstemmed | Lithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression. |
| title_short | Lithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression. |
| title_sort | lithium increases 5 ht mediated neuroendocrine responses in tricyclic resistant depression |
| work_keys_str_mv | AT cowenp lithiumincreases5htmediatedneuroendocrineresponsesintricyclicresistantdepression AT mccances lithiumincreases5htmediatedneuroendocrineresponsesintricyclicresistantdepression AT cohenp lithiumincreases5htmediatedneuroendocrineresponsesintricyclicresistantdepression AT julierd lithiumincreases5htmediatedneuroendocrineresponsesintricyclicresistantdepression |