Neurophysiological features of STN LFP underlying sleep fragmentation in Parkinson’s disease
Background: Sleep fragmentation is a persistent problem throughout the course of Parkinson’s disease (PD). However, the related neurophysiological patterns and the underlying mechanisms remained unclear. Method: We recorded subthalamic nucleus (STN) local field potentials (LFPs) using deep brain sti...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024
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| _version_ | 1826314845022060544 |
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| author | Zhang, G Yu, H Chen, Y Gong, C Hao, H Guo, Y Xu, S Zhang, Y Yuan, X Yin, G Zhang, J Tan, H Li, L |
| author_facet | Zhang, G Yu, H Chen, Y Gong, C Hao, H Guo, Y Xu, S Zhang, Y Yuan, X Yin, G Zhang, J Tan, H Li, L |
| author_sort | Zhang, G |
| collection | OXFORD |
| description | Background: Sleep fragmentation is a persistent problem throughout the course of Parkinson’s disease (PD). However, the related neurophysiological patterns and the underlying mechanisms remained unclear. Method: We recorded subthalamic nucleus (STN) local field potentials (LFPs) using deep brain stimulation (DBS) with real-time wireless recording capacity from 13 patients with PD undergoing a one-night polysomnography recording, 1 month after DBS surgery before initial programming and when the patients were off-medication. The STN LFP features that characterised different sleep stages, correlated with arousal and sleep fragmentation index, and preceded stage transitions during N2 and REM sleep were analysed. Results: Both beta and low gamma oscillations in non-rapid eye movement (NREM) sleep increased with the severity of sleep disturbance (arousal index (ArI)-betaNREM: r=0.9, p=0.0001, sleep fragmentation index (SFI)-betaNREM: r=0.6, p=0.0301; SFI-gammaNREM: r=0.6, p=0.0324). We next examined the low-to-high power ratio (LHPR), which was the power ratio of theta oscillations to beta and low gamma oscillations, and found it to be an indicator of sleep fragmentation (ArI-LHPRNREM: r=−0.8, p=0.0053; ArI-LHPRREM: r=−0.6, p=0.0373; SFI-LHPRNREM: r=−0.7, p=0.0204; SFI-LHPRREM: r=−0.6, p=0.0428). In addition, long beta bursts (>0.25 s) during NREM stage 2 were found preceding the completion of transition to stages with more cortical activities (towards Wake/N1/REM compared with towards N3 (p<0.01)) and negatively correlated with STN spindles, which were detected in STN LFPs with peak frequency distinguishable from long beta bursts (STN spindle: 11.5 Hz, STN long beta bursts: 23.8 Hz), in occupation during NREM sleep (β=−0.24, p<0.001). Conclusion: Features of STN LFPs help explain neurophysiological mechanisms underlying sleep fragmentations in PD, which can inform new intervention for sleep dysfunction. Trial registration number: NCT02937727. |
| first_indexed | 2024-09-25T04:16:43Z |
| format | Journal article |
| id | oxford-uuid:34d1d425-8a6c-487b-b001-4f5a5512f157 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:14:35Z |
| publishDate | 2024 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:34d1d425-8a6c-487b-b001-4f5a5512f1572024-10-16T09:40:48ZNeurophysiological features of STN LFP underlying sleep fragmentation in Parkinson’s diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:34d1d425-8a6c-487b-b001-4f5a5512f157EnglishJisc Publications RouterBMJ Publishing Group2024Zhang, GYu, HChen, YGong, CHao, HGuo, YXu, SZhang, YYuan, XYin, GZhang, JTan, HLi, LBackground: Sleep fragmentation is a persistent problem throughout the course of Parkinson’s disease (PD). However, the related neurophysiological patterns and the underlying mechanisms remained unclear. Method: We recorded subthalamic nucleus (STN) local field potentials (LFPs) using deep brain stimulation (DBS) with real-time wireless recording capacity from 13 patients with PD undergoing a one-night polysomnography recording, 1 month after DBS surgery before initial programming and when the patients were off-medication. The STN LFP features that characterised different sleep stages, correlated with arousal and sleep fragmentation index, and preceded stage transitions during N2 and REM sleep were analysed. Results: Both beta and low gamma oscillations in non-rapid eye movement (NREM) sleep increased with the severity of sleep disturbance (arousal index (ArI)-betaNREM: r=0.9, p=0.0001, sleep fragmentation index (SFI)-betaNREM: r=0.6, p=0.0301; SFI-gammaNREM: r=0.6, p=0.0324). We next examined the low-to-high power ratio (LHPR), which was the power ratio of theta oscillations to beta and low gamma oscillations, and found it to be an indicator of sleep fragmentation (ArI-LHPRNREM: r=−0.8, p=0.0053; ArI-LHPRREM: r=−0.6, p=0.0373; SFI-LHPRNREM: r=−0.7, p=0.0204; SFI-LHPRREM: r=−0.6, p=0.0428). In addition, long beta bursts (>0.25 s) during NREM stage 2 were found preceding the completion of transition to stages with more cortical activities (towards Wake/N1/REM compared with towards N3 (p<0.01)) and negatively correlated with STN spindles, which were detected in STN LFPs with peak frequency distinguishable from long beta bursts (STN spindle: 11.5 Hz, STN long beta bursts: 23.8 Hz), in occupation during NREM sleep (β=−0.24, p<0.001). Conclusion: Features of STN LFPs help explain neurophysiological mechanisms underlying sleep fragmentations in PD, which can inform new intervention for sleep dysfunction. Trial registration number: NCT02937727. |
| spellingShingle | Zhang, G Yu, H Chen, Y Gong, C Hao, H Guo, Y Xu, S Zhang, Y Yuan, X Yin, G Zhang, J Tan, H Li, L Neurophysiological features of STN LFP underlying sleep fragmentation in Parkinson’s disease |
| title | Neurophysiological features of STN LFP underlying sleep fragmentation in Parkinson’s disease |
| title_full | Neurophysiological features of STN LFP underlying sleep fragmentation in Parkinson’s disease |
| title_fullStr | Neurophysiological features of STN LFP underlying sleep fragmentation in Parkinson’s disease |
| title_full_unstemmed | Neurophysiological features of STN LFP underlying sleep fragmentation in Parkinson’s disease |
| title_short | Neurophysiological features of STN LFP underlying sleep fragmentation in Parkinson’s disease |
| title_sort | neurophysiological features of stn lfp underlying sleep fragmentation in parkinson s disease |
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