Islet allograft rejection can be mediated by CD4+, alloantigen experienced, direct pathway T cells of TH1 and TH2 cytokine phenotype.

BACKGROUND: It is widely believed that Thl cells that secrete interferon-gamma are primarily involved in the rejection of allografts whereas Th2 cells [interleukin(IL) 4 and IL-10] are thought to be protective of this process. However, the exact role and specificity of these helper T lymphocytes in...

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Main Authors: Barbara, J, Turvey, SE, Kingsley, C, Spriewald, B, Hara, M, Witzke, O, Morris, P, Wood, K
格式: Journal article
语言:English
出版: 2000