5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent classical psychedelic known to induce changes in locomotion, behaviour, and sleep in rodents. However, there is limited knowledge regarding its acute neurophysiological effects. Local field potentials (LFPs) are commonly used as a proxy for ne...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Nature Research
2024
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| _version_ | 1817930970625474560 |
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| author | Souza, AC Souza, BC França, A Moradi, M Souza, NC Leão, KE Tort, ABL Leão, RN Lopes-dos-Santos, V Ribeiro, S |
| author_facet | Souza, AC Souza, BC França, A Moradi, M Souza, NC Leão, KE Tort, ABL Leão, RN Lopes-dos-Santos, V Ribeiro, S |
| author_sort | Souza, AC |
| collection | OXFORD |
| description | 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent classical psychedelic known to induce changes in locomotion, behaviour, and sleep in rodents. However, there is limited knowledge regarding its acute neurophysiological effects. Local field potentials (LFPs) are commonly used as a proxy for neural activity, but previous studies investigating psychedelics have been hindered by confounding effects of behavioural changes and anaesthesia, which alter these signals. To address this gap, we investigated acute LFP changes in the hippocampus (HP) and medial prefrontal cortex (mPFC) of freely behaving rats, following 5-MeO-DMT administration. 5-MeO-DMT led to an increase of delta power and a decrease of theta power in the HP LFPs, which could not be accounted for by changes in locomotion. Furthermore, we observed a dose-dependent reduction in slow (20–50 Hz) and mid (50–100 Hz) gamma power, as well as in theta phase modulation, even after controlling for the effects of speed and theta power. State map analysis of the spectral profile of waking behaviour induced by 5-MeO-DMT revealed similarities to electrophysiological states observed during slow-wave sleep (SWS) and rapid-eye-movement (REM) sleep. Our findings suggest that the psychoactive effects of classical psychedelics are associated with the integration of waking behaviours with sleep-like spectral patterns in LFPs. |
| first_indexed | 2024-09-25T04:13:32Z |
| format | Journal article |
| id | oxford-uuid:34da69a0-f025-466e-a936-2849c2cff4ab |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:14:35Z |
| publishDate | 2024 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:34da69a0-f025-466e-a936-2849c2cff4ab2024-10-16T09:40:55Z5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake ratsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:34da69a0-f025-466e-a936-2849c2cff4abEnglishJisc Publications RouterNature Research2024Souza, ACSouza, BCFrança, AMoradi, MSouza, NCLeão, KETort, ABLLeão, RNLopes-dos-Santos, VRibeiro, S5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent classical psychedelic known to induce changes in locomotion, behaviour, and sleep in rodents. However, there is limited knowledge regarding its acute neurophysiological effects. Local field potentials (LFPs) are commonly used as a proxy for neural activity, but previous studies investigating psychedelics have been hindered by confounding effects of behavioural changes and anaesthesia, which alter these signals. To address this gap, we investigated acute LFP changes in the hippocampus (HP) and medial prefrontal cortex (mPFC) of freely behaving rats, following 5-MeO-DMT administration. 5-MeO-DMT led to an increase of delta power and a decrease of theta power in the HP LFPs, which could not be accounted for by changes in locomotion. Furthermore, we observed a dose-dependent reduction in slow (20–50 Hz) and mid (50–100 Hz) gamma power, as well as in theta phase modulation, even after controlling for the effects of speed and theta power. State map analysis of the spectral profile of waking behaviour induced by 5-MeO-DMT revealed similarities to electrophysiological states observed during slow-wave sleep (SWS) and rapid-eye-movement (REM) sleep. Our findings suggest that the psychoactive effects of classical psychedelics are associated with the integration of waking behaviours with sleep-like spectral patterns in LFPs. |
| spellingShingle | Souza, AC Souza, BC França, A Moradi, M Souza, NC Leão, KE Tort, ABL Leão, RN Lopes-dos-Santos, V Ribeiro, S 5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats |
| title | 5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats |
| title_full | 5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats |
| title_fullStr | 5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats |
| title_full_unstemmed | 5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats |
| title_short | 5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats |
| title_sort | 5 meo dmt induces sleep like lfp spectral signatures in the hippocampus and prefrontal cortex of awake rats |
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