The molecular structure of cell adhesion molecules.
Considerable advances have been made in our knowledge of the molecular structure of cell adhesion molecules, their binding sites, and adhesion complexes. For the cadherins, protein zero, and CD2, additional experimental data support the insights obtained from structural analysis of their domains and...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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1997
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| _version_ | 1826266705994711040 |
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| author | Chothia, C Jones, E |
| author_facet | Chothia, C Jones, E |
| author_sort | Chothia, C |
| collection | OXFORD |
| description | Considerable advances have been made in our knowledge of the molecular structure of cell adhesion molecules, their binding sites, and adhesion complexes. For the cadherins, protein zero, and CD2, additional experimental data support the insights obtained from structural analysis of their domains and molecular models of their adhesion complexes. For neural cell adhesion molecules, L1, fibronectin, tenascin-C, integrins, and vascular cell adhesion molecules, the molecular structure of domains, and in most cases their binding sites, have been elucidated. The substrate recognition sites in some of these molecules possess rate constants for association and dissociation that permit both rapid cell migration and, through avidity, high-affinity cell-cell interactions. |
| first_indexed | 2024-03-06T20:43:02Z |
| format | Journal article |
| id | oxford-uuid:34e4cb73-0950-4ab9-97e3-192c483d02e1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:43:02Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:34e4cb73-0950-4ab9-97e3-192c483d02e12022-03-26T13:28:54ZThe molecular structure of cell adhesion molecules.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:34e4cb73-0950-4ab9-97e3-192c483d02e1EnglishSymplectic Elements at Oxford1997Chothia, CJones, EConsiderable advances have been made in our knowledge of the molecular structure of cell adhesion molecules, their binding sites, and adhesion complexes. For the cadherins, protein zero, and CD2, additional experimental data support the insights obtained from structural analysis of their domains and molecular models of their adhesion complexes. For neural cell adhesion molecules, L1, fibronectin, tenascin-C, integrins, and vascular cell adhesion molecules, the molecular structure of domains, and in most cases their binding sites, have been elucidated. The substrate recognition sites in some of these molecules possess rate constants for association and dissociation that permit both rapid cell migration and, through avidity, high-affinity cell-cell interactions. |
| spellingShingle | Chothia, C Jones, E The molecular structure of cell adhesion molecules. |
| title | The molecular structure of cell adhesion molecules. |
| title_full | The molecular structure of cell adhesion molecules. |
| title_fullStr | The molecular structure of cell adhesion molecules. |
| title_full_unstemmed | The molecular structure of cell adhesion molecules. |
| title_short | The molecular structure of cell adhesion molecules. |
| title_sort | molecular structure of cell adhesion molecules |
| work_keys_str_mv | AT chothiac themolecularstructureofcelladhesionmolecules AT jonese themolecularstructureofcelladhesionmolecules AT chothiac molecularstructureofcelladhesionmolecules AT jonese molecularstructureofcelladhesionmolecules |