Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.

The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)...

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Main Authors: Aulchenko, Y, Hoppenbrouwers, I, Ramagopalan, S, Broer, L, Jafari, N, Hillert, J, Link, J, Lundström, W, Greiner, E, Dessa Sadovnick, A, Goossens, D, Van Broeckhoven, C, Del-Favero, J, Ebers, G, Oostra, B, van Duijn, C, Hintzen, R
格式: Journal article
语言:English
出版: 2008