Post-translational site-selective protein backbone α-deuteration

Isotopic replacement has long-proven applications in small molecules. However, applications in proteins are largely limited to biosynthetic strategies or exchangeable (for example, N-H/D) labile sites only. The development of postbiosynthetic, C-1H → C-2H/D replacement in proteins could enable probi...

詳細記述

書誌詳細
主要な著者: Galan, S, Wickens, J, Dadova, J, Ng, W, Zhang, X, Simion, R, Quinlan, R, Pires, E, Paton, R, Caddick, S, Chudasama, V, Davis, B
フォーマット: Journal article
言語:English
出版事項: Springer Nature 2018