Post-translational site-selective protein backbone α-deuteration

Post-translational site-selective protein backbone α-deuteration

Isotopic replacement has long-proven applications in small molecules. However, applications in proteins are largely limited to biosynthetic strategies or exchangeable (for example, N-H/D) labile sites only. The development of postbiosynthetic, C-1H → C-2H/D replacement in proteins could enable probi...

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Dettagli Bibliografici
Autori principali:	Galan, S, Wickens, J, Dadova, J, Ng, W, Zhang, X, Simion, R, Quinlan, R, Pires, E, Paton, R, Caddick, S, Chudasama, V, Davis, B
Natura:	Journal article
Lingua:	English
Pubblicazione:	Springer Nature 2018

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