Public engagement during a typhoid conjugate vaccine trial in Lalitpur, Nepal- experience, challenges and lessons learnt
Typhoid is a public health problem in Nepal. To generate evidence on the impact of Typhoid Conjugate Vaccine (TCV), a phase 3, double-blind, randomized controlled trial was conducted in Lalitpur, Nepal. 20,000 children aged between 9 months and ≤16 years were vaccinated with a new TCV, or control va...
| Huvudupphovsmän: | , , , , , , , , |
|---|---|
| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
Taylor and Francis
2022
|
| _version_ | 1826308134966132736 |
|---|---|
| author | Dahal, A Shakya, M Pant, D Adhikari, A Colin-Jones, R Theiss-Nyland, K Pollard, AJ Basnyat, B Shrestha, S |
| author_facet | Dahal, A Shakya, M Pant, D Adhikari, A Colin-Jones, R Theiss-Nyland, K Pollard, AJ Basnyat, B Shrestha, S |
| author_sort | Dahal, A |
| collection | OXFORD |
| description | Typhoid is a public health problem in Nepal. To generate evidence on the impact of Typhoid Conjugate Vaccine (TCV), a phase 3, double-blind, randomized controlled trial was conducted in Lalitpur, Nepal. 20,000 children aged between 9 months and ≤16 years were vaccinated with a new TCV, or control vaccine. Participants were actively followed for safety and efficacy over 2 years through passive surveillance (PS) clinics. Several challenges were encountered during vaccination and PS stemming from misinformation, misconception, and fear around clinical trials in the community. Public engagement (PE) activities were conducted across various tiers moving from decision makers in the first tier; to elected local representatives in the second tier; ending with interaction in community with parents/guardians of the targeted population. Prior and during vaccination, engagement was conducted to inform about the study and discuss the importance of vaccination. Post-vaccination, engagement was conducted to inform about PS clinics, alleviate study concerns and share study updates. Direct and continuous interaction with community stakeholders, including parents/guardians of the targeted population contributed to build trust around the study and community willingness to be involved. It helped to raise awareness, drive away misconceptions, and allowed adaptation according to feedback from community members. |
| first_indexed | 2024-03-07T07:13:32Z |
| format | Journal article |
| id | oxford-uuid:351f56e8-4c6d-4a83-8f22-6d03b2fd1476 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:13:32Z |
| publishDate | 2022 |
| publisher | Taylor and Francis |
| record_format | dspace |
| spelling | oxford-uuid:351f56e8-4c6d-4a83-8f22-6d03b2fd14762022-07-21T13:35:38ZPublic engagement during a typhoid conjugate vaccine trial in Lalitpur, Nepal- experience, challenges and lessons learntJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:351f56e8-4c6d-4a83-8f22-6d03b2fd1476EnglishSymplectic ElementsTaylor and Francis2022Dahal, AShakya, MPant, DAdhikari, AColin-Jones, RTheiss-Nyland, KPollard, AJBasnyat, BShrestha, STyphoid is a public health problem in Nepal. To generate evidence on the impact of Typhoid Conjugate Vaccine (TCV), a phase 3, double-blind, randomized controlled trial was conducted in Lalitpur, Nepal. 20,000 children aged between 9 months and ≤16 years were vaccinated with a new TCV, or control vaccine. Participants were actively followed for safety and efficacy over 2 years through passive surveillance (PS) clinics. Several challenges were encountered during vaccination and PS stemming from misinformation, misconception, and fear around clinical trials in the community. Public engagement (PE) activities were conducted across various tiers moving from decision makers in the first tier; to elected local representatives in the second tier; ending with interaction in community with parents/guardians of the targeted population. Prior and during vaccination, engagement was conducted to inform about the study and discuss the importance of vaccination. Post-vaccination, engagement was conducted to inform about PS clinics, alleviate study concerns and share study updates. Direct and continuous interaction with community stakeholders, including parents/guardians of the targeted population contributed to build trust around the study and community willingness to be involved. It helped to raise awareness, drive away misconceptions, and allowed adaptation according to feedback from community members. |
| spellingShingle | Dahal, A Shakya, M Pant, D Adhikari, A Colin-Jones, R Theiss-Nyland, K Pollard, AJ Basnyat, B Shrestha, S Public engagement during a typhoid conjugate vaccine trial in Lalitpur, Nepal- experience, challenges and lessons learnt |
| title | Public engagement during a typhoid conjugate vaccine trial in Lalitpur, Nepal- experience, challenges and lessons learnt |
| title_full | Public engagement during a typhoid conjugate vaccine trial in Lalitpur, Nepal- experience, challenges and lessons learnt |
| title_fullStr | Public engagement during a typhoid conjugate vaccine trial in Lalitpur, Nepal- experience, challenges and lessons learnt |
| title_full_unstemmed | Public engagement during a typhoid conjugate vaccine trial in Lalitpur, Nepal- experience, challenges and lessons learnt |
| title_short | Public engagement during a typhoid conjugate vaccine trial in Lalitpur, Nepal- experience, challenges and lessons learnt |
| title_sort | public engagement during a typhoid conjugate vaccine trial in lalitpur nepal experience challenges and lessons learnt |
| work_keys_str_mv | AT dahala publicengagementduringatyphoidconjugatevaccinetrialinlalitpurnepalexperiencechallengesandlessonslearnt AT shakyam publicengagementduringatyphoidconjugatevaccinetrialinlalitpurnepalexperiencechallengesandlessonslearnt AT pantd publicengagementduringatyphoidconjugatevaccinetrialinlalitpurnepalexperiencechallengesandlessonslearnt AT adhikaria publicengagementduringatyphoidconjugatevaccinetrialinlalitpurnepalexperiencechallengesandlessonslearnt AT colinjonesr publicengagementduringatyphoidconjugatevaccinetrialinlalitpurnepalexperiencechallengesandlessonslearnt AT theissnylandk publicengagementduringatyphoidconjugatevaccinetrialinlalitpurnepalexperiencechallengesandlessonslearnt AT pollardaj publicengagementduringatyphoidconjugatevaccinetrialinlalitpurnepalexperiencechallengesandlessonslearnt AT basnyatb publicengagementduringatyphoidconjugatevaccinetrialinlalitpurnepalexperiencechallengesandlessonslearnt AT shresthas publicengagementduringatyphoidconjugatevaccinetrialinlalitpurnepalexperiencechallengesandlessonslearnt |