Enzymatic inactivation of endogenous IgG by IdeS enhances therapeutic antibody efficacy

Enzymatic inactivation of endogenous IgG by IdeS enhances therapeutic antibody efficacy

Endogenous plasma IgG sets an immunological threshold that dictates the activity of tumor-directed therapeutic antibodies. Saturation of cellular antibody receptors by endogenous antibody limits antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP)....

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Bibliografiske detaljer
Main Authors:	Järnum, S, Runström, A, Bockermann, R, Winstedt, L, Crispin, M, Kjellman, C
Format:	Journal article
Sprog:	English
Udgivet:	American Association for Cancer Research 2017

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