Resistance analysis of genotype 3 hepatitis C virus indicates subtypes inherently resistant to nonstructural protein 5A inhibitors

Resistance analysis of genotype 3 hepatitis C virus indicates subtypes inherently resistant to nonstructural protein 5A inhibitors

Hepatitis C virus (HCV) genotype (gt) 3 is highly prevalent globally, with non‐gt3a subtypes common in Southeast Asia. Resistance‐associated substitutions (RASs) have been shown to play a role in treatment failure. However, the role of RASs in gt3 is not well understood. We report the prevalence of...

Descripció completa

Dades bibliogràfiques
Autors principals:	Smith, D, Magri, A, Bonsall, D, Ip, C, Trebes, A, Brown, A, Piazza, P, Bowden, R, Nguyen, D, STOP-HCV Consortium, Ansari, M, Simmonds, P, Barnes, E
Format:	Journal article
Publicat:	American Association for the Study of Liver Diseases 2018

Ítems similars

Comparison of next generation sequencing technologies for the comprehensive assessment of full-length hepatitis C viral genomes
per: Ip, C, et al.
Publicat: (2016)

Efficacy of NS5A inhibitors against unusual and potentially difficult-to-treat HCV subtypes commonly found in sub Saharan Africa and South East Asia
per: Nguyen, D, et al.
Publicat: (2020)

ve-SEQ: Robust, unbiased enrichment for streamlined detection and whole-genome sequencing of HCV and other highly diverse pathogens
per: Bowden, R, et al.
Publicat: (2015)

Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus
per: Ansari, M, et al.
Publicat: (2017)

Impact of IFNL4 genotype on interferon-stimulated gene expression during daa therapy for Hepatitis C
per: Ramamurthy, N, et al.
Publicat: (2018)

Comparison of next generation sequencing technologies for the comprehensive assessment of full-length hepatitis C viral genomes.
per: Thomson, E, et al.
Publicat: (2016)

Evaluation of viremia frequencies of a novel human pegivirus by using bioinformatic screening and PCR
per: Bonsall, D, et al.
Publicat: (2016)

Analysis of Transcriptome and Terpene Constituents of Scots Pine Genotypes Inherently Resistant or Susceptible to Heterobasidion annosum
per: Mengxia Liu, et al.
Publicat: (2022-07-01)

Aphid Resistance: An Overlooked Ecological Dimension of Nonstructural Carbohydrates in Cereals
per: Victor O. Sadras, et al.
Publicat: (2020-06-01)

Inference of Host–Pathogen Interaction Matrices from Genome-Wide Polymorphism Data
per: Märkle, H, et al.
Publicat: (2024)

Inference of Host–Pathogen Interaction Matrices from Genome-Wide Polymorphism Data
per: Märkle, H, et al.
Publicat: (2024)

Characterisation of hepatitis C virus recombination in Cameroon using non-specific next generation sequencing.
per: Iles, J, et al.
Publicat: (2015)

Host genetic factors associated with hepatocellular carcinoma in patients with hepatitis C virus infection: A systematic review
per: Walker, A, et al.
Publicat: (2018)

Impact of virus subtype and host IFNL4 genotype on large-scale RNA structure formation in the genome of hepatitis C virus
per: Simmonds, P, et al.
Publicat: (2020)

Evidence That the Nonstructural Protein of Tomato spotted wilt virus Is the Avirulence Determinant in the Interaction with Resistant Pepper Carrying the Tsw Gene
per: P. Margaria, et al.
Publicat: (2007-05-01)

Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure
per: David A. Smith, et al.
Publicat: (2021-10-01)

Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis
per: Vineet D. Menachery, et al.
Publicat: (2017-12-01)

Analysis of the susceptibility of refractory hepatitis C virus resistant to nonstructural 5A inhibitors
per: Ai Toyodome, et al.
Publicat: (2024-07-01)

Whole-genome characterization and resistance-associated substitutions in a new HCV genotype 1 subtype
per: von Massow G, et al.
Publicat: (2019-04-01)

Characterization of hepatitis C virus resistance to grazoprevir reveals complex patterns of mutations following on-treatment breakthrough that are not observed at relapse
per: Bonsall, D, et al.
Publicat: (2018)

Interferon lambda 4 impacts the genetic diversity of hepatitis C virus
per: M Azim Ansari, et al.
Publicat: (2019-09-01)

Thermoelectric polymer-matrix structural and nonstructural composite materials
per: D.D.L. Chung
Publicat: (2018-10-01)

Inherent and Composite Hydrogels as Promising Materials to Limit Antimicrobial Resistance
per: Rahela Carpa, et al.
Publicat: (2022-01-01)

PERK Is Critical for Alphavirus Nonstructural Protein Translation
per: Bibha Dahal, et al.
Publicat: (2021-05-01)

Nonstructural barriers to adult vaccination
per: T. Mark Doherty, et al.
Publicat: (2024-12-01)

Genetic Subtypes and Natural Resistance Mutations in HCV Genotype 4 Infected Saudi Arabian Patients
per: Mariantonietta Di Stefano, et al.
Publicat: (2021-09-01)

Evaluation of Viremia Frequencies of a Novel Human Pegivirus by Using Bioinformatic Screening and PCR
per: David Bonsall, et al.
Publicat: (2016-04-01)

Inherent and acquired resistance to paclitaxel in hepatocellular carcinoma: molecular events involved.
per: Avtar Singh Meena, et al.
Publicat: (2013-01-01)

Identification of the phenotypic, genotypic and fitness correlates of non-B subtype HIV-1 NRTI resistance through longitudinal analysis of children with virological failure in the developing world
per: Mbisa, J, et al.
Publicat: (2010)

Castanet: a pipeline for rapid analysis of targeted multi-pathogen genomic data
per: Mayne, R, et al.
Publicat: (2024)

Nonstructural proteins of alphavirus—potential targets for drug development
per: Abu Bakar, Farhana, et al.
Publicat: (2018)

Nonstructural Proteins of Alphavirus—Potential Targets for Drug Development
per: Farhana Abu Bakar, et al.
Publicat: (2018-02-01)

Structural and Nonstructural Genes Contribute to the Genetic Diversity of RNA Viruses
per: Natalie D. Collins, et al.
Publicat: (2018-11-01)

Functional studies of the coronavirus nonstructural proteins
per: Yanglin Qiu, et al.
Publicat: (2020-03-01)

Technical Validation of a Hepatitis C Virus Whole Genome Sequencing Assay for Detection of Genotype and Antiviral Resistance in the Clinical Pathway
per: Carmen F. Manso, et al.
Publicat: (2020-10-01)

Comparison of next-generation sequencing technologies for comprehensive assessment of full-length hepatitis C viral genomes
per: Thomson, E, et al.
Publicat: (2016)

Genetic antimicrobial resistance determinants and their prevalence in molecular subtypes of Treponema pallidum subsp. pallidum
per: Obraztsova O.A., et al.
Publicat: (2018-08-01)

Processing of the Hepatitis E virus ORF1 nonstructural polyprotein
per: Yogesh A. Karpe, et al.
Publicat: (2024-01-01)

The inherently political nature of subsidiarity
per: Burbidge, D
Publicat: (2017)

Standardization of quantitative dengue virus nonstructural-1 ELISA for quantitation of dengue virus nonstructural-1 levels in human serum
per: Puneet Bhatt, et al.
Publicat: (2023-01-01)