Mdm2 targets the p53 transcription cofactor JMY for degradation.

Mdm2 targets the p53 transcription cofactor JMY for degradation.

We define here a new mechanism through which Mdm2 (mouse double minute 2) regulates p53 activity, by targeting the p53 transcription cofactor JMY. DNA damage causes an increase in JMY protein, and, in a similar manner, small molecule inhibitors of Mdm2 activity induce JMY in unperturbed cells. At a...

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Bibliographic Details
Main Authors:	Coutts, A, Boulahbel, H, Graham, A, La Thangue, N
Format:	Journal article
Language:	English
Published:	2007

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