Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985-2001.

Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985-2001.

Despite the success of contemporary treatment protocols in childhood acute lymphoblastic leukaemia (ALL), relapse within the central nervous system (CNS) remains a challenge. To better understand this phenomenon, we have analysed the changes in incidence and pattern of CNS relapses in 5564 children...

Full description

Bibliographic Details
Main Authors:	Krishnan, S, Wade, R, Moorman, A, Mitchell, C, Kinsey, SE, Eden, T, Parker, C, Vora, A, Richards, S, Saha, V
Format:	Journal article
Language:	English
Published:	2010

Similar Items

Intraocular relapse of childhood acute lymphoblastic leukaemia.
by: Somervaille, T, et al.
Published: (2003)

Late relapsing childhood lymphoblastic leukaemia.
by: Frost, L, et al.
Published: (1997)

Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial.
by: Mitchell, C, et al.
Published: (2005)

Late relapsing childhood acute lymphoblastic leukaemia.
by: Frost, L, et al.
Published: (1998)

The impact of risk stratification by early bone-marrow response in childhood lymphoblastic leukaemia: results from the United Kingdom Medical Research Council trial ALL97 and ALL97/99.
by: Mitchell, C, et al.
Published: (2009)

Thioguanine compared with mercaptopurine in childhood lymphoblastic leukaemia: Results of the United Kingdom medical research council randomised trial ALL97.
by: Lennard, L, et al.
Published: (2005)

Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-2001.
by: Mitchell, C, et al.
Published: (2010)

Benefit of targeted intensification for NCI high risk childhood lymphoblastic leukaemia: Results of the United Kingdom medical research council trial ALL97 and ALL97/99.
by: Vora, A, et al.
Published: (2006)

The clinical pharmacology of thioguanine vs. mercaptopurine in ALL97, a randomized trial for the treatment of childhood lymphoblastic leukaemia
by: Lennard, L, et al.
Published: (2008)

Thioguanine-related veno-occlusive disease (VOD) of the liver in children with acute lymphoblastic leukaemia (ALL): Report from United Kingdom Medical Research Council (UK MRC) trial ALL97.
by: Vora, A, et al.
Published: (2002)

Delineation of Risk Factors in Paediatric Acute Lymphoblastic Leukaemia with Favourable Cytogenetics
by: Moorman, A, et al.
Published: (2012)

Benefit of intensified treatment for all children with acute lymphoblastic leukaemia: results from MRC UKALL XI and MRC ALL97 randomised trials. UK Medical Research Council's Working Party on Childhood Leukaemia.
by: Hann, I, et al.
Published: (2000)

Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial.
by: Moorman, A, et al.
Published: (2010)

Outcome of central nervous system relapses in childhood acute lymphoblastic leukaemia--prospective open cohort analyses of the ALLR3 trial.
by: Masurekar, A, et al.
Published: (2014)

Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial.
by: Vora, A, et al.
Published: (2006)

The UK experience in treating relapsed childhood acute lymphoblastic leukaemia: a report on the medical research council UKALLR1 study.
by: Lawson, SE, et al.
Published: (2000)

Testicular irradiation in childhood lymphoblastic leukaemia. Medical Research Council Working Party on Leukemia in Childhoods.
by: Eden, O, et al.
Published: (1990)

Acute lymphoblastic leukaemia in infancy: experience in MRC UKALL trials. Report from the Medical Research Council Working Party on Childhood Leukaemia.
by: Chessells, J, et al.
Published: (1994)

Improved Outcome for Children and Young Adults with T-Cell Acute Lymphoblastic Leukaemia (ALL): Results of the United Kingdom Medical Research Council (MRC) Trial UKALL 2003
by: Vora, A, et al.
Published: (2008)

Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia.
by: Morris, E, et al.
Published: (2003)

Analysis of the immunophenotype of children treated on the Medical Research Council United Kingdom Acute Lymphoblastic Leukaemia Trial XI (MRC UKALLXI). Medical Research Council Childhood Leukaemia Working Party.
by: Hann, I, et al.
Published: (1998)

Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia.
by: Harrison, C, et al.
Published: (2004)

Variables affecting kinetics of minimal residual disease clearance in children with lymphoblastic leukaemia; Results of the United Kingdom Medical Research Council (UK MRC) protocols ALL97, ALL97/99 and ALL2003.
by: Vora, A, et al.
Published: (2005)

Efficacy and Toxicity of Pegylated Asparaginase in the Treatment of Children and Young Adults with Acute Lymphoblastic Leukaemia: Results of the United Kingdom Medical Research Council (MRC) Trial UKALL 2003
by: Vora, A, et al.
Published: (2008)

Comparison of bone marrow transplant and chemotherapy for relapsed childhood acute lymphoblastic leukaemia: the MRC UKALL X experience. Medical Research Council Working Party on Childhood Leukaemia.
by: Wheeler, K, et al.
Published: (1998)

Outcome of central nervous system relapses in childhood acute lymphoblastic leukaemia--prospective open cohort analyses of the ALLR3 trial.
by: Ashish Narayan Masurekar, et al.
Published: (2014-01-01)

TEL-AML1 fusion in childhood acute lymphoblastic leukaemia (ALL): Demographics, clinical features, cytogenetic characteristics and prognosis
by: Moorman, A, et al.
Published: (2005)

Incidence and Outcome of Osteonecrosis in Children and Young Adults with Acute Lymphoblastic Leukaemia Treated on a Dexamethasone Containing Protocol: Results of the Medical Research Council UK Trial ALL 2003
by: Vora, A, et al.
Published: (2008)

Cytomorphology of childhood lymphoblastic leukaemia: a prospective study of 2000 patients. United Kingdom Medical Research Council's Working Party on Childhood Leukaemia.
by: Lilleyman, J, et al.
Published: (1992)

The thiopurine methyltransferase TPMT *1/*3A genotype is associated with a better treatment outcome in the UK ALL97 trial for childhood acute lymphoblastic leukaemia; TPMT heterozygosity is not associated with secondary cancers
by: Lennard, L, et al.
Published: (2010)

Progressive reduction in treatment-related deaths in Medical Research Council childhood lymphoblastic leukaemia trials from 1980 to 1997 (UKALL VIII, X and XI).
by: Hargrave, DR, et al.
Published: (2001)

Treatment of high risk leukaemia - Results of MRC childhood acute lymphoblastic leukaemia study MRC HR-1.
by: Kinsey, S, et al.
Published: (2002)

Intraocular relapse of childhood acute lymphoblastic leukemia.
by: Somervaille, T, et al.
Published: (2002)

Evolving strategies in the management of relapsed acute lymphoblastic leukaemia – TMCKidsALLR1
by: Prakriti Roy, et al.
Published: (2017-01-01)

Long-term follow-up of the United Kingdom Medical Research Council protocols for childhood acute lymphoblastic leukaemia, 1980-1997. Medical Research Council Childhood Leukaemia Working Party.
by: Eden, O, et al.
Published: (2000)

Periodic acid Schiff reaction in childhood lymphoblastic leukaemia. The Medical Research Council Working Party on Childhood Leukaemia.
by: Lilleyman, J, et al.
Published: (1994)

Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol.
by: Patrick, K, et al.
Published: (2014)

Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol
by: Patrick, K, et al.
Published: (2014)

Cytogenetic-specific heterogeneity in the kinetics of minimal residual disease (MIRD) clearance in childhood lymphoblastic leukaemia (ALL)
by: Moorman, A, et al.
Published: (2008)

The Spectrum and Prognostic Relevance of Additional Abnormalities, Involving 12p and 21q, in Children with ETV6-RUNX1 Positive Acute Lymphoblastic Leukaemia (ALL)
by: Moorman, A, et al.
Published: (2008)