HIV-related arterial stiffness in Malawian adults is associated with proportion of PD-1 expressing CD8 T-cells and reverses with anti-retroviral therapy
<strong>Background</strong> The contribution of immune activation to arterial stiffness and its reversibility in HIV-infected adults in sub-Saharan Africa is unknown. <strong>Methods</strong> HIV-uninfected and HIV-infected Malawian adults initiating antiretroviral therapy (...
| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Journal article |
| Lingua: | English |
| Pubblicazione: |
Oxford University Press
2019
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| _version_ | 1826309261362200576 |
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| author | Kelly, C Mwandumba, HC Heyderman, RS Jambo, K Kamng'ona, R Chammudzi, M Sheha, I Peterseon, I Rapala, A Mallewa, J Walker, AS Klein, N Khoo, S |
| author_facet | Kelly, C Mwandumba, HC Heyderman, RS Jambo, K Kamng'ona, R Chammudzi, M Sheha, I Peterseon, I Rapala, A Mallewa, J Walker, AS Klein, N Khoo, S |
| author_sort | Kelly, C |
| collection | OXFORD |
| description | <strong>Background</strong> The contribution of immune activation to arterial stiffness and its reversibility in HIV-infected adults in sub-Saharan Africa is unknown. <strong>Methods</strong> HIV-uninfected and HIV-infected Malawian adults initiating antiretroviral therapy (ART) with CD4 <100 cells/l were enrolled (2-weeks post-ART for HIV-infected) and followed for 44-weeks. We evaluated the relationship between carotid femoral pulse wave velocity (cfPWV) and T-cell activation (HLADR+CD38+), exhaustion (PD1+) and senescence (CD57+), and monocyte subsets using normal regression. <strong>Results</strong> In 279 HIV-infected and 110 HIV-uninfected adults, 142(37%) had hypertension. HIV was independently associated with 12% higher cfPWV (p=0.02) at baseline, and week-10 (14% higher, p=0.02) but resolved by week-22. CD4 and CD8 T-cell exhaustion(PD1+) were independently associated with higher cfPWV at baseline (p=0.02). At 44-weeks, arterial stiffness improved more in those with greater decreases in %CD8 and %CD8PD1+ T-cells (p=0.01, p=0.03 respectively). When considering HIV-infected participants alone, adjusted arterial stiffness at week-44 tended to be lower in those with higher baseline %CD8PD1+ T-cells (p=0.054). <strong>Conclusions</strong> PD-1+ expressing CD8 T-cells are associated with HIV-related arterial stiffness, which remains elevated during the first three months on ART. Resources to prevent cardiovascular disease in sub-Saharan Africa should focus on blood pressure reduction, and those with low CD4 during early ART. |
| first_indexed | 2024-03-07T07:31:32Z |
| format | Journal article |
| id | oxford-uuid:356e8ee4-209c-4782-8708-db8edbd96fae |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:31:32Z |
| publishDate | 2019 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:356e8ee4-209c-4782-8708-db8edbd96fae2023-02-02T10:06:29ZHIV-related arterial stiffness in Malawian adults is associated with proportion of PD-1 expressing CD8 T-cells and reverses with anti-retroviral therapyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:356e8ee4-209c-4782-8708-db8edbd96faeEnglishSymplectic Elements at OxfordOxford University Press2019Kelly, CMwandumba, HCHeyderman, RSJambo, KKamng'ona, RChammudzi, MSheha, IPeterseon, IRapala, AMallewa, JWalker, ASKlein, NKhoo, S<strong>Background</strong> The contribution of immune activation to arterial stiffness and its reversibility in HIV-infected adults in sub-Saharan Africa is unknown. <strong>Methods</strong> HIV-uninfected and HIV-infected Malawian adults initiating antiretroviral therapy (ART) with CD4 <100 cells/l were enrolled (2-weeks post-ART for HIV-infected) and followed for 44-weeks. We evaluated the relationship between carotid femoral pulse wave velocity (cfPWV) and T-cell activation (HLADR+CD38+), exhaustion (PD1+) and senescence (CD57+), and monocyte subsets using normal regression. <strong>Results</strong> In 279 HIV-infected and 110 HIV-uninfected adults, 142(37%) had hypertension. HIV was independently associated with 12% higher cfPWV (p=0.02) at baseline, and week-10 (14% higher, p=0.02) but resolved by week-22. CD4 and CD8 T-cell exhaustion(PD1+) were independently associated with higher cfPWV at baseline (p=0.02). At 44-weeks, arterial stiffness improved more in those with greater decreases in %CD8 and %CD8PD1+ T-cells (p=0.01, p=0.03 respectively). When considering HIV-infected participants alone, adjusted arterial stiffness at week-44 tended to be lower in those with higher baseline %CD8PD1+ T-cells (p=0.054). <strong>Conclusions</strong> PD-1+ expressing CD8 T-cells are associated with HIV-related arterial stiffness, which remains elevated during the first three months on ART. Resources to prevent cardiovascular disease in sub-Saharan Africa should focus on blood pressure reduction, and those with low CD4 during early ART. |
| spellingShingle | Kelly, C Mwandumba, HC Heyderman, RS Jambo, K Kamng'ona, R Chammudzi, M Sheha, I Peterseon, I Rapala, A Mallewa, J Walker, AS Klein, N Khoo, S HIV-related arterial stiffness in Malawian adults is associated with proportion of PD-1 expressing CD8 T-cells and reverses with anti-retroviral therapy |
| title | HIV-related arterial stiffness in Malawian adults is associated with proportion of PD-1 expressing CD8 T-cells and reverses with anti-retroviral therapy |
| title_full | HIV-related arterial stiffness in Malawian adults is associated with proportion of PD-1 expressing CD8 T-cells and reverses with anti-retroviral therapy |
| title_fullStr | HIV-related arterial stiffness in Malawian adults is associated with proportion of PD-1 expressing CD8 T-cells and reverses with anti-retroviral therapy |
| title_full_unstemmed | HIV-related arterial stiffness in Malawian adults is associated with proportion of PD-1 expressing CD8 T-cells and reverses with anti-retroviral therapy |
| title_short | HIV-related arterial stiffness in Malawian adults is associated with proportion of PD-1 expressing CD8 T-cells and reverses with anti-retroviral therapy |
| title_sort | hiv related arterial stiffness in malawian adults is associated with proportion of pd 1 expressing cd8 t cells and reverses with anti retroviral therapy |
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