Maternal infection in pregnancy and childhood leukaemia: a systematic review and meta-analysis
<p><strong>Objective</strong></p> <p>To summarize the published evidence regarding the association between maternal infection during pregnancy and childhood leukemia.</p> <p><strong>Study design</strong></p> <p>In this systematic rev...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2019
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| _version_ | 1797062419725418496 |
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| author | He, J-R Ramakrishnan, R Hirst, JE Bonaventure, A Francis, SS Paltiel, O Håberg, SE Lemeshow, S Olsen, S Tikellis, G Magnus, P Murphy, MFG Wiemels, JL Linet, MS Dwyer, T |
| author_facet | He, J-R Ramakrishnan, R Hirst, JE Bonaventure, A Francis, SS Paltiel, O Håberg, SE Lemeshow, S Olsen, S Tikellis, G Magnus, P Murphy, MFG Wiemels, JL Linet, MS Dwyer, T |
| author_sort | He, J-R |
| collection | OXFORD |
| description | <p><strong>Objective</strong></p>
<p>To summarize the published evidence regarding the association between maternal infection during pregnancy and childhood leukemia.</p>
<p><strong>Study design</strong></p>
<p>In this systematic review and meta-analysis (PROSPERO number, CRD42018087289), we searched PubMed and Embase to identify relevant studies. We included human studies that reported associations of at least one measure of maternal infection during pregnancy with acute lymphoblastic leukemia (ALL) or all childhood leukemias in the offspring. One reviewer extracted the data first using a standardized form, and the second reviewer independently checked the data for accuracy. Two reviewers used the Newcastle-Ottawa Scale to assess the quality of included studies. We conducted random effects meta-analyses to pool the ORs of specific type of infection on ALL and childhood leukemia.</p>
<p><strong>Results</strong></p>
<p>This review included 20 studies (ALL, n = 15; childhood leukemia, n = 14) reported in 32 articles. Most (>65%) included studies reported a positive association between infection variables and ALL or childhood leukemia. Among specific types of infection, we found that influenza during pregnancy was associated with higher risk of ALL (pooled OR, 3.64; 95% CI, 1.34-9.90) and childhood leukemia (pooled OR, 1.77; 95% CI, 1.01-3.11). Varicella (pooled OR, 10.19; 95% CI, 1.98-52.39) and rubella (pooled OR, 2.79; 95% CI, 1.16-6.71) infections were also associated with higher childhood leukemia risk.</p>
<p><strong>Conclusions</strong></p>
<p>Our findings suggest that maternal infection during pregnancy may be associated with a higher risk of childhood leukemia.</p> |
| first_indexed | 2024-03-06T20:45:17Z |
| format | Journal article |
| id | oxford-uuid:35ae155c-dc83-41cb-9430-602e4c7d2a8f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:45:17Z |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:35ae155c-dc83-41cb-9430-602e4c7d2a8f2022-03-26T13:33:25ZMaternal infection in pregnancy and childhood leukaemia: a systematic review and meta-analysisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:35ae155c-dc83-41cb-9430-602e4c7d2a8fEnglishSymplectic Elements at OxfordElsevier2019He, J-RRamakrishnan, RHirst, JEBonaventure, AFrancis, SSPaltiel, OHåberg, SELemeshow, SOlsen, STikellis, GMagnus, PMurphy, MFGWiemels, JLLinet, MSDwyer, T<p><strong>Objective</strong></p> <p>To summarize the published evidence regarding the association between maternal infection during pregnancy and childhood leukemia.</p> <p><strong>Study design</strong></p> <p>In this systematic review and meta-analysis (PROSPERO number, CRD42018087289), we searched PubMed and Embase to identify relevant studies. We included human studies that reported associations of at least one measure of maternal infection during pregnancy with acute lymphoblastic leukemia (ALL) or all childhood leukemias in the offspring. One reviewer extracted the data first using a standardized form, and the second reviewer independently checked the data for accuracy. Two reviewers used the Newcastle-Ottawa Scale to assess the quality of included studies. We conducted random effects meta-analyses to pool the ORs of specific type of infection on ALL and childhood leukemia.</p> <p><strong>Results</strong></p> <p>This review included 20 studies (ALL, n = 15; childhood leukemia, n = 14) reported in 32 articles. Most (>65%) included studies reported a positive association between infection variables and ALL or childhood leukemia. Among specific types of infection, we found that influenza during pregnancy was associated with higher risk of ALL (pooled OR, 3.64; 95% CI, 1.34-9.90) and childhood leukemia (pooled OR, 1.77; 95% CI, 1.01-3.11). Varicella (pooled OR, 10.19; 95% CI, 1.98-52.39) and rubella (pooled OR, 2.79; 95% CI, 1.16-6.71) infections were also associated with higher childhood leukemia risk.</p> <p><strong>Conclusions</strong></p> <p>Our findings suggest that maternal infection during pregnancy may be associated with a higher risk of childhood leukemia.</p> |
| spellingShingle | He, J-R Ramakrishnan, R Hirst, JE Bonaventure, A Francis, SS Paltiel, O Håberg, SE Lemeshow, S Olsen, S Tikellis, G Magnus, P Murphy, MFG Wiemels, JL Linet, MS Dwyer, T Maternal infection in pregnancy and childhood leukaemia: a systematic review and meta-analysis |
| title | Maternal infection in pregnancy and childhood leukaemia: a systematic review and meta-analysis |
| title_full | Maternal infection in pregnancy and childhood leukaemia: a systematic review and meta-analysis |
| title_fullStr | Maternal infection in pregnancy and childhood leukaemia: a systematic review and meta-analysis |
| title_full_unstemmed | Maternal infection in pregnancy and childhood leukaemia: a systematic review and meta-analysis |
| title_short | Maternal infection in pregnancy and childhood leukaemia: a systematic review and meta-analysis |
| title_sort | maternal infection in pregnancy and childhood leukaemia a systematic review and meta analysis |
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