The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.
The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the recent co...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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| _version_ | 1797062432208715776 |
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| author | Dustin, M Cooper, J |
| author_facet | Dustin, M Cooper, J |
| author_sort | Dustin, M |
| collection | OXFORD |
| description | The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the recent convergence of cell biology and immunology studies to explain the role of the actin cytoskeleton in creating the molecular basis for immunological synapse formation and T cell signaling. |
| first_indexed | 2024-03-06T20:45:27Z |
| format | Journal article |
| id | oxford-uuid:35bc1ce8-b5e9-4854-a604-828f9a88586d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:45:27Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:35bc1ce8-b5e9-4854-a604-828f9a88586d2022-03-26T13:33:41ZThe immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:35bc1ce8-b5e9-4854-a604-828f9a88586dEnglishSymplectic Elements at Oxford2000Dustin, MCooper, JThe actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the recent convergence of cell biology and immunology studies to explain the role of the actin cytoskeleton in creating the molecular basis for immunological synapse formation and T cell signaling. |
| spellingShingle | Dustin, M Cooper, J The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. |
| title | The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. |
| title_full | The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. |
| title_fullStr | The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. |
| title_full_unstemmed | The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. |
| title_short | The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. |
| title_sort | immunological synapse and the actin cytoskeleton molecular hardware for t cell signaling |
| work_keys_str_mv | AT dustinm theimmunologicalsynapseandtheactincytoskeletonmolecularhardwarefortcellsignaling AT cooperj theimmunologicalsynapseandtheactincytoskeletonmolecularhardwarefortcellsignaling AT dustinm immunologicalsynapseandtheactincytoskeletonmolecularhardwarefortcellsignaling AT cooperj immunologicalsynapseandtheactincytoskeletonmolecularhardwarefortcellsignaling |