Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation

Histone acetyltransferases of the MYST family are recruited to chromatin by BRPF scaffolding proteins. We explored functional consequences and the therapeutic potential of inhibitors targeting acetyl-lysine dependent protein interaction domains (bromodomains) present in BRPF1-3 in bone maintenance....

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Những tác giả chính:	Meier, JC, Tallant, C, Fedorov, O, Witwicka, H, Hwang, SY, van Stiphout, RG, Lambert, JP, Rogers, C, Yapp, C, Gerstenberger, BS, Fedele, V, Savitsky, P, Heidenreich, D, Daniels, DL, Owen, DR, Fish, PV, Igoe, NM, Bayle, ED, Haendler, B, Oppermann, UCT, Buffa, F, Brennan, PE, Müller, S, Gingras, AC, Odgren, PR, Birnbaum, MJ, Knapp, S
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	American Chemical Society 2017

Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation

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