Daytime variation in hepatitis C virus replication kinetics following liver transplant
<strong>Background:</strong> There is a growing interest in the role of circadian regulated pathways in disease pathogenesis. <strong>Methods:</strong> In a cohort of hepatitis C virus (HCV) infected patients undergoing liver transplantation, we observed differences in early...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
F1000Research
2018
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| Summary: | <strong>Background:</strong> There is a growing interest in the role of circadian regulated pathways in disease pathogenesis. <strong>Methods:</strong> In a cohort of hepatitis C virus (HCV) infected patients undergoing liver transplantation, we observed differences in early viral infection kinetics of the allograft that associated with the time of liver transplant. <strong>Results:</strong> A higher frequency of subjects transplanted in the morning showed a rebound in viral RNA levels (n=4/6) during the first week post-surgery. In contrast, no viral rebound was observed in seven subjects transplanted in the afternoon. None of the other parameters previously reported to influence viral replication in the post-transplant setting, such as donor age, cold-ischemia time and length of surgery associated with viral rebound. <strong>Conclusions:</strong> These observation highlights a role for circadian processes to regulate HCV infection of the liver and warrants further investigation. |
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