Daytime variation in hepatitis C virus replication kinetics following liver transplant
<strong>Background:</strong> There is a growing interest in the role of circadian regulated pathways in disease pathogenesis. <strong>Methods:</strong> In a cohort of hepatitis C virus (HCV) infected patients undergoing liver transplantation, we observed differences in early...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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F1000Research
2018
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| _version_ | 1826266882571763712 |
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| author | Zhuang, X Lai, A McKeating, J Rowe, I Balfe, P |
| author_facet | Zhuang, X Lai, A McKeating, J Rowe, I Balfe, P |
| author_sort | Zhuang, X |
| collection | OXFORD |
| description | <strong>Background:</strong> There is a growing interest in the role of circadian regulated pathways in disease pathogenesis. <strong>Methods:</strong> In a cohort of hepatitis C virus (HCV) infected patients undergoing liver transplantation, we observed differences in early viral infection kinetics of the allograft that associated with the time of liver transplant. <strong>Results:</strong> A higher frequency of subjects transplanted in the morning showed a rebound in viral RNA levels (n=4/6) during the first week post-surgery. In contrast, no viral rebound was observed in seven subjects transplanted in the afternoon. None of the other parameters previously reported to influence viral replication in the post-transplant setting, such as donor age, cold-ischemia time and length of surgery associated with viral rebound. <strong>Conclusions:</strong> These observation highlights a role for circadian processes to regulate HCV infection of the liver and warrants further investigation. |
| first_indexed | 2024-03-06T20:45:41Z |
| format | Journal article |
| id | oxford-uuid:35cea60f-addf-42d7-bbf6-2c6783c368d4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:45:41Z |
| publishDate | 2018 |
| publisher | F1000Research |
| record_format | dspace |
| spelling | oxford-uuid:35cea60f-addf-42d7-bbf6-2c6783c368d42022-03-26T13:34:11ZDaytime variation in hepatitis C virus replication kinetics following liver transplantJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:35cea60f-addf-42d7-bbf6-2c6783c368d4EnglishSymplectic Elements at OxfordF1000Research2018Zhuang, XLai, AMcKeating, JRowe, IBalfe, P<strong>Background:</strong> There is a growing interest in the role of circadian regulated pathways in disease pathogenesis. <strong>Methods:</strong> In a cohort of hepatitis C virus (HCV) infected patients undergoing liver transplantation, we observed differences in early viral infection kinetics of the allograft that associated with the time of liver transplant. <strong>Results:</strong> A higher frequency of subjects transplanted in the morning showed a rebound in viral RNA levels (n=4/6) during the first week post-surgery. In contrast, no viral rebound was observed in seven subjects transplanted in the afternoon. None of the other parameters previously reported to influence viral replication in the post-transplant setting, such as donor age, cold-ischemia time and length of surgery associated with viral rebound. <strong>Conclusions:</strong> These observation highlights a role for circadian processes to regulate HCV infection of the liver and warrants further investigation. |
| spellingShingle | Zhuang, X Lai, A McKeating, J Rowe, I Balfe, P Daytime variation in hepatitis C virus replication kinetics following liver transplant |
| title | Daytime variation in hepatitis C virus replication kinetics following liver transplant |
| title_full | Daytime variation in hepatitis C virus replication kinetics following liver transplant |
| title_fullStr | Daytime variation in hepatitis C virus replication kinetics following liver transplant |
| title_full_unstemmed | Daytime variation in hepatitis C virus replication kinetics following liver transplant |
| title_short | Daytime variation in hepatitis C virus replication kinetics following liver transplant |
| title_sort | daytime variation in hepatitis c virus replication kinetics following liver transplant |
| work_keys_str_mv | AT zhuangx daytimevariationinhepatitiscvirusreplicationkineticsfollowinglivertransplant AT laia daytimevariationinhepatitiscvirusreplicationkineticsfollowinglivertransplant AT mckeatingj daytimevariationinhepatitiscvirusreplicationkineticsfollowinglivertransplant AT rowei daytimevariationinhepatitiscvirusreplicationkineticsfollowinglivertransplant AT balfep daytimevariationinhepatitiscvirusreplicationkineticsfollowinglivertransplant |